A Study On Relativity Of TCM Constitution In Patients With Psoriasis Vulgaris And The Severity Of The Disease

Objective:To explore the relativity of TCM constitution in patients with Psoriasis Vulgaris and the severity of the disease for identificating TCM constitution type of patients with the disease and for their TCM therapy,prevention,such as preventive nursing.Methods:The 195 inpatients and outpatients from 18 to 65 full years old whose symptoms comformed to the diagnostic criteria for psoriasis vulgaris with a certain degree of reading comprehension,willingness to cooperate were chosen.We kept a record of lesions of the patients with PASI scores,VAS scores and made a questionare about basic epidemiological data such as risk factors.The patients filled in the SDS scale and the SAS scale,and we turned their outcomes into SDS standard scores and SAS standard scores.And they also filled in the "TCM Constitution Scale" based on the TCM Constitution which created by Professor WangQi to diagnose pateints' TCM Constitution type.We divided the subjective and objective indicators(PASI scores,,SDS standard scores,SAS standard scores) separately into serious and non-serious groups,and made statistical analysis.SPSS13.0 for windows Chi-square test, Rank sum test,ANOVA test and multiple logistic regression analysis,Bivariate Correlations were used in this research..Results:1.The most common types of TCM constitution in Psoriasis vulgaris patients in the research were Ping he zhi(21%),Yang xu zhi(18%),Yin xu zhi(14%)and Qi xu zhi(12%).There were more Yin xu zhi men than women,and more yang xu zhi women than men.The ratios of the nine TCM constitution in different age groups showed no statistical significance(P＞0.05). 2.Yin xu zhi had the highest median and the highest median rank sum of PASI scores in the nine TCM constitution types,but the differences between various types are no statistical significance(χ~2=3.97,P= 0.860＞0.05). In Case-control study,we used different TCM constitution types as single-factor and made single-factor analysis between them and the severity of psoriasis lesions.However,there was no statistical significance (P＞0.05).The type differences of the nine TCM constitution between the severity of lesions were not significant(χ~2 = 22.749,P = 0.04＜0.05) by multiple Logistic regression analysis.3.The type differences of the nine TCM constitution between both SDS standard scores(P=0.011＜0.05) and SAS standard scores(P=0.004＜0.05) were significant.The differences between Ping he zhi and other types such as Qi xu zhi,Yang xu zhi,Yin xu zhi,Tan shi zhi and Qi yu zhi in both SDS standard scores and SAS standard scores were statistically significant(P＜0.05).Qi xu zhi,Yin xu zhi and Qi yu zhi might be risk factors of the severity of depression(χ~2 =18.43,P=0.031＜0.05).The OR made by Logistic regression releaved that the risk of Qi xu zhi effecting the the severity of depression was 5.705 times than that of the non-Qi xu zhi doing;The OR made by Logistic regression,releaved that the risk of Yin xu zhi effecting the the severity of depression was 5.634 times than that of the non-Yin xu zhi doing;The OR made by Logistic regression,releaved that the risk of Qi yu zhi effecting the the severity of depression was 3.645 times than that of the non-Qi yu zhi doing.Non Ping he zhi might be a risk factor of the severity of anxiety(χ~2 =15.331,P=0.000＜0.05).The OR made by Logistic regression,releaved that the risk of non-Ping he zhi effecting the the severity of anxiety was 7.050 times than that of the Ping he zhi doing.4.PASI scores and subject indicators such as SDS standard scores and VAS scores were highly positively interrelated(P＜0.01 for each combination). Statistically significant correlations were also found between PASI scores and SAS standard scores(P＜0.05).VAS scores were positively correlated with SAS standard scores(P＜0.05),but it failed to reach a correlation with SDS standard scores(P＞0.05).There was a significant positive interrelated between SDS standard scores and SAS standard scores with a correlation coefficient of 0.764(P＜0.01).Conclusion:1.The most common types of TCM constitution in Psoriasis vulgaris patients in the research were Ping he zhi,Yang xu zhi,Yin xu zhi and Qi xu zhi.2.Yin xu zhi may tend to be a risk factor of the severity of lesions;Qi xu zhi,Yin xu zhi and Qi yu zhi may tend to be risk factors of the severity of depression;Non Ping he zhi tend to be risk factor of the severity of anxiety.3.The more serious the lesions were,the more serious itching,depression and anxiety it would be.The more serious degree of depression patients got,the more serious degree of anxiety they would suffer.