| Objective (1) To investigate into the relationship between neuron-specific enolase in plasm and the scores of nervous impariment and the influence in two indexes by micro-invasive puncture surgery in the patients with hypertensive intracerebral hemorrhage. (2) To observe the changing laws of Chinese medicine's syndrome in patients with hypertensive intracerebral hemorrhage before and after micro-invasive puncture surgery and to explore the influence of Chinese medicine's syndrome .(3) To analyze correlation of Chinese medicine's syndrome and levels of NES in plasm was made to establish the objective diagnosis to the different Chinese medicine's syndrome of HICH .Methods Between 2007/03 and 2008/02, 68 patients who were nonambulators with HICH (<48h from onset )were retrospectively included at Department of Neurology of Min Dong hospital of Ningde City. All cases were divided into micro-invasive puncture surgery group and routine treatment group according to permission and were treated immediately in the hospital. The levels of NSE were measured on being in hospital,3d,7d, 14d and 30d. In the same time,the Chinese medicine's syndrome type of 68 patients was differentiated.Result The levels of NSE in plasm before 24 h onset of HICH, raised significantly on 3 day, decreased after 7d ,more significantly after 14d and 30d, They were lower significantly in micro-invasive puncture surgery group than in routine treatment group, while the neural function deficiency score was significantly lower in the micro-invasive puncture surgery group than that in the routine treatment group on the 30th day after treatment; Before treatment of micro-invasive puncture surgery, syndrome types of TanShiMengShen,FengHuoShangRao,FengTanHuoKang and FengTanYuZu were the commonest, while QiXuXueYu,YinXuFengDong and FengTanYuZhu were the most commonly syndrome types after treatment. Comparison of the syndrome types between before and after the micro-invasive puncture surgery within 1 month showed that the syndromes of deficiency did not change, while syndromes of TanShiMengShen,FengHuoShangRao,FengTanHuoKang remarkably have changed; In the different syndrome types of HICH, the level of NSE of ones is obviously distinguishing than others, excepting QiXuXueYu,TanShiMengShen,FengTanHuoKang and the level of NSE in Feng HuoShang- Rao,QiXuXueYu,FengTanHuoKang and TanShiMengShen is obviously higer.Conclusion Micro-invasive puncture surgery could reduce the level of NSE of HICH and improve neural function through reducing brain injury, superiority over the routine treatment, curative effect of micro-invasive puncture surgery in HICH can be evaluated objectively based on the level of NSE; Although micro-invasive puncture surgery treatment could relieve patients' symptoms of excess in superficiality, it can't radically change the pathogenetic nature of HICH , namely, the deficiency in origin and excess in superficiality, which indicates that one should pay full attention to the importance and necessity of HICH after micro-invasive puncture surgery; The nervous impairment of HICH could be dignosed according to Chinese medicine's syndrome type, the research is going to richen and complete the theory of TCM (traditional Chinese medicine). |
