Studies On Chemical Constituents Of Rosa Laevigata Michx

Rosa laevigata Michx.is the fruit of Rosa laevigata Michx.in Rosaceae,it was recorded in "Shu Materia Medica"at first,and has some other names such as Ci Yu Zi,Ci Li Zi,Jin Yao Zi,Shan Shi Liu and Tang Guan Zi.It was widely distributed in the east,middle-south and southwest of China^[1].As a traditional chinese medicine Rosa laevigata Michx.was recorded in "Compendium of Materia Medica" to treat dysentery,piss convenience,Shibuya fine gas.^[2]By means of column chromatographic Silica gel,Diaion HP-20,ODS,Sephadex LH-20, HPLC and so on,the investigation on the chemical constituents of the 70%ethanol extracts of Rosa laevigata Michx.has resulted in the isolation and structure elucidation of eighteen compounds named Ursolic acid(1),Pomolic acid(2),Euscaphic acid(3),1α,2α,3β,19α-tetrahydroxyurs-12-en-28-oic acid(4),19α-hydroxyasiatic acid(5),Myrianthic acid(6),Oleanolic acid(7),Maslinic acid(8),2α,3α-dihydroxyolean-12-en-28-oic acid(9),2α,3β,19α-trihydroxyolean-12-en-28-oic acid(10),2α,3β-dihydroxylup-20(29)-en-28-oic acid(11),2α,3β, 23-trihydroxylup-20(29)-en-28-oicacid(12),19α-hydroxyasiaticacid-28-O-β-D-glucopyrannoside(13), Tormentic acid-28-O-β-D-glucopyrannoside(14),β-sitosterol(15),Daucosterol (16),PotengriffiosideA(17),Kaempferol(18).Among them,compound 2,4,8,9,10,11,12were isolated from this plant for the first time.