The Clinical Research About The Efficacy Of Qingrehuoxue Chinese Medicine In Unstable Angina

Objective:To observe the efficacy of Qingrehuoxue Chinese Traditional Medicine in Unstable Angina(UA), and explore its possible mechanism. To confirm that the important mechanism of Xiongbixintong disease is yure. Methods:50 cases of UA patients were randomly divided into two groups: experimental group and control group. All the patients of two groups were given standard treatment of the modern medicine, including: general medical treatment;drug treatment(anti-platelet therapy,Antithrombin treatment, nitrates, calcium channel blocks(CCB) andβ-receptor blocker); the treatment for other related complications, for example hypertension, diabetes and lipid disorders.At the same time, patients of the experimental group were given the decoction of Qingrehuoxue Chinese Herbs(Scutellaria 10 g, honeysuckle 10 g, Gardenia 10g, guanxin II, including: safflower 10 g, lignum dalbergiae odoriferae 10 g,Salvia miltiorrhiza 15 g, rhizoma ligustici wallichii 15 g, rot of peony 15 g);patients of the control group were given the decoction of huoxue Chinese Herbs(guanxin II, including: safflower 10 g, lignum dalbergiae odoriferae 10 g, Salvia miltiorrhiza 15 g, rhizoma ligustici wallichii 15 g, rot of peony 15 g).The treatment last for two weeks ( 14 days). And then, assess the effects through evaluating clinical symptoms integral, ECG symptoms and measuring the concentration of C-reactive protein, fibrinogen and D-dimer in the plasma, comparing that after treatment with before, and that of the experimental group with control group , to observe efficacy of Qingrehuoxue Chinese Herbs in Unstable Angina, and to explore the possible mechanism. Results:After two weeks of treatment, the clinical symptoms integral and ECG symptoms of both group have reached a higher efficiency (70%-96%); the concentrations of C-reactive protein, fibrinogen and D - Dimer in plasma decreased significantly, each differences of both groups were statistically significant (P <0.01). Compared with the control group, the symptoms efficacy of the experimental group didn't show obvious advantage, there was no significant difference between the two groups. But after treatment, the experimental group's decline of the concentrations of C-reactive protein, fibrinogen and D - Dimer in plasma were larger than the control group's, and the differences were statistically significant (C-reactive protein: P<0.01, fibrinogen: P<0.05, D-dimer:P<0.05)Conclusion:Although there was no statistically significant difference in the clinical symptoms evaluation between the experimental group and control group, but through the analysis of laboratory indicators we can see that Qingrehuoxue Chinese Herbs can reduce the concentrations of C-reactive protein, fibrinogen and D-dimer of the UA patients more effectively, So that, they are more effective in inhibiting the body's inflammatory response, lowering blood viscosity and blood hypercoagulability, and so it maybe can protect vascular endothelial cells, regulate the secretion of vasoactive substances, stable coronary atherosclerosis, inhibit local thrombosis, and thus play a positive role in treatment of UA. That further prove that yure pathogenesis accounts for an important position in UA(xiongbixintong disease).