| Purpose:In clinical Yiqihuoxue Yang Xin Tang (hospital preparations) on the efficacy and safety of the instability of angina (with Qi), and Analysis of its mechanism of action and its pharmacological effects, in order to more widelymore effective, more accurate clinical use, and further lay the foundation for to study Yiqihuoxue Yang Xin Tang.Material and method:1Clinical data:from the Dalian Municipal Hospital of Traditional Chinese Medicine Department of Cardiology, hospitalized patients, from December2010to December2011period, in line with the Medical Society of Cardiology in2007will be published with unstable angina and non-ST-segment elevation myocardial infarction diagnosis and treatment guidelines [I] and the Traditional Chinese Drug treatment of angina pectoris guidelines for clinical research (2002)[2] made with unstable angina (QDBS) diagnosis and in accordance with the requirements of this study.84patients for the study. Completely random grouping method constitute the treatment group (n=44cases) and control group (n=40cases)2Medical ion:the control group to the treatment of unstable angina, conventional western medicine; treatment group on the basis of conventional western medicine plus Yiqihuoxue Yang Xin Tang (hospital preparations), were treated for14days. Symptomatic treatment of hypertension, diabetes and other diseases,1do not impact studies corresponding Western.3Research indicators:observed two groups of patients before and after the change of clinical symptoms and other minor symptoms, ECG, blood lipids series and HS-CRP changes4Statistical methods were used:According to different data types x2, t-tes and statistical processing. Results:1Symptoms effects:After treatment, the total score of clinical symptoms were significantly lower, and statistically significant; all the symptom scores of the treatment group and control group, part of the symptom score decreased significantly, there is a significant difference compared with before treatment(P<0.01); lower individual symptom scores in the two groups after treatment there was significant difference (P<0.01), and the treatment group was significantly better than the control group. That clinical symptoms are significantly improved, but the treatment group than the control group and treatment group can be an overall improvement in the patient’s symptoms.2ECG:EGG of the treatment group markedly effective rate was29.5%,82.0%of the total effective rate; markedly effective rate was10.0%in the control group, the total effective rate was60.0%. The two sets of ECG after treatment showed significant improvement in the treatment group was significantly better than the control group and treatment group electrocardiogram effective rate than the control.group, with statistical significa3lipids:of TG, TC, LDL-C HDL-C in the treatment group showed significant improvement, no obvious improvement in the control group.3Blood lipids:the two groups after treatment of TG, TC, LDL-C, HDL-C showed significant improvement in the treatment group demonstrated greater improvement than the control group, and the effect of lowering cholesterol (TC) treatment group was significantly better than the control group.4Comparison:the treatment group, significantly lower HS-CRP, was not changed significantly in the control group5Changes in the liver and kidney function:the two groups before and after treatment, ALT, AST, and of Cr, BUN and four key indicators had no significant change (P>0.05). Conclusion:lYiqihuoxue Yang Xin Tang in the treatment of unstable angina (QDBS). significant improvement in the ECG effectively relieve angina attack, at the same time, can also be an overall improvement in other symptoms, increase patient comfort and lifequality; found no adverse reactions, with good security.2Improve blood Iipids (especially cholesterol-lowering), does not harm the liver and kidney function,3Lower HS-CRP and endothelial protective function. |
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