Investigation Of Influence On Acupuncture To The Feeding Model IR Rat On GLUT4 IRS1

Destination:Acupuncture research on insulin resistance in rats the impact of insulin resistance, and acupuncture to prevent further explore the mechanism of insulin resistanceExperimental methods:Health Wistar male rats were divided into the normal control group,model,scalp acupuncture group,and back Shuxue acupuncture groups,each with eight.The establishment of a high fat diet fed rats IR,scalp acupuncture group were the first points Cong acupuncture,back Shuxue acupuncture group from Pishu,Shenshu increase pancreatic Shuxue,treatment for two weeks;By RIA analysis of plasma insulin(FINS), automatic biochemical analyzer in fasting plasma glucose test(FBG),cholesterol(TC), triglycerides(TG),measured insulin sensitivity index(ISI)and weight(BW)and other relevant indicators,clear IR model success and the efficacy of acupuncture;using immunohistochemical study of skeletal muscle cells of rats in each group IRS1 and GLUT4 expression.Consequence:1.Model group BW,FINS,TG were significantly higher than normal,and the ISI has decreased significantly(P＜0.05);FINS in the acupuncture group was significantly lower than the model,ISI is a marked increase(p＜0.05),different Between the acupuncture group had no significant difference(P＞0.05);model group than the normal group FBG, TC increase was not significant(P＞0.05);the acupuncture group than the model group BW,TG There was no significant decrease(P＞0.05).2.Immunohistochemistry results showed that the IR model rat skeletal muscle GLUT4, IRS1 than normal expression was significantly weakened by acupuncture interventions will enable GLUT4,IRS1 of expression,but back Shuxue scalp acupuncture group and the difference between the groups do not Significant.Conclusion:1.Acupuncture significantly increased IR rats insulin sensitivity index,so that the normal trend,the situation has improved insulin resistance.2.Acupuncture can make IR rat insulin signaling pathway in the IRS1 expression,and promote the insulin IRS1/PI3-Kt way signaling pathway in the GLUT4 translocation,IR improvement in peripheral tissue to insulin resistance,reducing hyperinsulinemia.