Studies On The Chemical Constituents Of The Stems And Leaves Of Calophyllum Inophyllum

Calophyllum inophyllum Linn belongs to Calophyllum genus(Guttiferae).Plants of the Calophyllum genus are known as a rich source of secondary metabolites such as coumarins,xanthones,flavonoids,chromenes,triterpenes,etc.Based on the review on the chemical constituents and pharmacological research of the genus Calophyllum,the chemical constituents of Calophyllum inophyllum Linn. are studied.The chemical constituents of 95%EtOH extract from the stems and leaves of C. inophyllum were studied systematically.Twenty-six compounds were isolated by repeated silica gel,sephadex LH-20,opening ODS column chromatography and preparative TLC.On the basis of spectral data and physicochemical characters,the structures of these compounds were identified as friedelin(1),friedelan-3β-ol(2), canophyllal(3),canophyllol(4),canophyllic acid(5),canophyllalic acid(6), taraxasterol(7),caloxanthone I(8),2-hydroxyxanthone(9), 2-methoxy-3-hydroxyxanthone(10),caloxanthone N(11),1,3,7-trihydroxyxanthone (12),pyranojacareubin(13),6-deoxyjacareubin(14),jacareubin(15),amentoflavone (16),quercitrin(17),12-methoxyinophyllum D(18),calophyllic acid and isocalophyllic acid(1:1)(19),inophyllum D(20),calophyllolide(21),stigrnasterol (22),clovane-2β,9α-diol(23),shikimic acid(24),gallic acid(25),and protocatechuic acid(26).Among them,compound 11 is a new compound,compounds 7 and 23 were obtained for the first time from Calophyllum genus and compounds 10 and 24 were isolated firstly from C.inophyllum.