Study On Distribution Rules Of Traditional Chinese Medicine Syndrome And Correlated Factors Of Polycystic Ovary Syndrome

Research Background:Polycystic ovary syndrome(PCOS)is a syndrome of endocrine disturbance participated by multiple factors.The morbidity in child-bearing women is 4%-12%,which is tend to rise in recent years.PCOS is the main cause of menstrual disorder and anovulatory infertility.It is a disease which has highly heterogeneity and a variety of clinical manifestation.It can manifested by abnormal menstruation(as oligomenorrhea,delayed menstruation, amenorrhea or irregular colporrhagia),infertility,obesity,hairiness,acne, acanthosis nigricans(AN),and hyperplasia of endometrium ang etc.It could increase the risk of gestational diabetes mellitus,pregnancy-induced hypertension,and long-term metabolic disease,such as endometrial cancer, diabetes,artherosclerosis,coronary heart disease,which seriously influence women' s life-quality.Therefore PCOS has already been a hot-spot and difficult problem in endocrinology,gynecology and angiocardiology.But the detailed nosogenesis of PCOS is still unclear.Reviewed the literature,it was said that the morbidity of PCOS may be correlated with potential genetic factor,high-lipin and high-protein diet and Psychic and psychological factors. Based on the summation of predecessors' experience,and the clinical practice, contemporary traditional Chinese medicine doctors consider that the etiology and pathomechanism of PCOS are deficiency of spleen and kidney,stagnation of phlegm-dampness,deficiency of kidney-yin,and qi stagnation and blood stasis,which refers to the liver,spleen,and kidney.PCOS is a syndrome that asthenia in the root and sthenia in the branch.The root is deficiency of kidney, and the branch is qi stagnation,blood and phlegm stasis.But there is no large sample study on distribution rule of traditional Chinese medicine syndrome and correlated factors of Polycystic ovary syndrome yet.Objective study the distribution rule of syndrome type in traditional Chinese medicine and correlated factors of Polycystic ovary syndrome,to summarized the epidemiology distribution rules of different TCM syndrome type,and to supply credible evidence for the study on etiology of PCOS and the correlation between development of pathogeny in TCM and objective modern medicine index.methods:Perspective study methods was used to register PCOS hospitalized and outpatient case information from Hospital of TCM of Guangdong Province and Hospital of TCM of Guangzhou in 1 year.Having set up base bank,entered data, we administrated the base bank and did statistical analysis with EPIdata3.2 and SPSSI3.0,and get conclusion.Results:1.the syndrome of deficiency of kidney-yang plays the primary role in the disease,the next is the syndrome of liver depression and phlegm turbidity, the third is the syndrome of deficiency of kidney and blood stasis and deficiency of kidney-yin,syndrome of qi Stagnation and blood stasis has lower proportion in this disease.2.Analysis of correlationship between factors and syndrome types of PCOS in traditional Chinese medicine(1)Age:case of the syndrome of deficiency of kidney-yang and phlegm turbidity is older than that of the syndrome of liver depression and deficiency of kidney-yin.(2)Heredity factor is a risk factor of syndrome of deficiency of kidney-yang, OR=3.194,P=0.0l7.(3)Spirit-psyche factor is a risk factor of syndrome of liver depression, OR=4.716,P=0.007.(4)High-fat diet and birth-weight are both risk factor of syndrome of phlegm turbidity.The OR is 7.111,5.000,P＜0.05,(5)Syndromes deficiency of kidney and blood stasis show no relationship wjth the clinical factors in this research.(6)Birth-length is a defend factor of deficiency of kidney-yin,OR=0.555, P=0.040.3.Analysis of correlation between clinical index and syndrome types of PCOS in traditional Chinese medicine PCOSThe clinical index,as BMI,WHR,fasting blood-glucose and insulin,are different in defferent syndrome type of PCOS,significance is statistical.The WHR of syndrome of phlegm turbidity is higher than that of deficiency of kidney-yang,deficiency of kidney-yin and liver depression;the BMI and fasting blood-insulin of syndrome of phlegm turbidity is higher than that of deficiency of kidney-yang,deficiency of kidney-yin,liver depression and deficiency of kidney and blood stasis;the fasting blood-glucose of syndrome of phlegm turbidity is higher than that of deficiency of kidney-yin.Conclusion:Syndrome differentiation in TCM of PCOS is related to some clinical factors and index to a certain extent.