| ObjectiveInvestigating the distribution rules of constitution and syndrome types in traditional Chinese medicine and the correlated factors of Polycystic ovary syndrome in Guangdong,to provide the scientific basis for the prevention and treatment of the Polycystic ovary syndrome.MethodsThe data of PCOS patients’information, which is about TCM Constitution、 TCM four diagnostic and the correlated factors, is got through survey by applying epidemiologic methods, and the data base is established by Microsoft Excel2007. For investigating the distribution rules of constitution and syndrome types in traditional Chinese medicine and the correlated factors of Polycystic ovary syndrome in Guangdong.Frequency analysis, descriptive statistics and Logistic regression analysis are used to do statistical analysis with SPSS17.0statistical software analysis.Results1.256PCOS patients met the inclusion criteria, which mainly ranged in age from21to30. The youngest was18years old, the oldest was43years old, average age was26.69±4.01years old. The geographical distribution of these patients was mainly concentrated in Guangzhou (86.7%), followed by Foshan (3.9%), Dongguan (2.7%), Huizhou (1.6%), Shenzhen and Qingyuan both accounted for1.2%, Heyuan (0.8%), Maoming, Zhuhai, Taishan, Yangjiang and Kaiping accounted for0.4%each.2.256PCOS patients diagnosed with irregular menstruation (65.2%), infertility (34.8%), and late menstrual was the most common clinical, manifestations of Irregular menstruation(88.7%).3.256cases of patients with PCOS, the movement:no exercise (16. a small amount of movement (72.3%), Moderate amount of movement (10.9%), a large amount of movement (0.4%). Diet:Meat eater (16.4%), vegetarian (12.9%), omnivores (70.7%). So, in this study, it was common in a small amount of movement and omnivorous diet.4. The main traditional Chinese medicine syndrome type in the256PCOS patients was dual deficiency of the spleen-kidney, second was kidney deficiency with blood stasis、spleen deficiency with phlegm-dampness、blood stasis due to qi stagnation, the third was kidney deficiency、kidney yin deficiency.And the dampness-heat、excess heat in the liver meridian、blood heat、kidney yang deficiency、blood stasis、dual deficiency of qi and blood、blood cold was the least syndrome type.5. The distribution of constitution types in256cases of Polycystic ovary syndrome were as follows:health(19.5%), qi deficiency (16.4%),yang deficiency(19.1%), yin deficiency (7.8%), phlegm-dampness (7.4%), dampness-heat (8.6%), blood stasis(3.1%), qi stagnation (15.2%), sensitiveness(2.7%). These results suggest that the patients were common in health, yang deficiency, qi deficiency and qi stagnation.6.256PCOS patients, who less than20years were common in health、qi deficiency、and qi stagnation(25.0%); ranged in age from21to30were common in yang deficiency(21.4%);more than31years were common in health(28.2%).7.256PCOS patients, health of whom were most common in kidney deficiency with blood stasis(26.0%), second were kidney deficiency (24.0%); qi deficiency of whom were most common in dual deficiency of the spleen-kidney (54.8%), second were kidney deficiency with blood stasis (21.4%); yang deficiency of whom were most common in dual deficiency of the spleen-kidney (55.1%), second were kidney deficiency with blood stasis (20.4%); yin deficiency of whom were most common in kidney yin deficiency (45.0%), second were kidney deficiency with blood stasis (30.0%); phlegm-dampness of whom were most common in spleen deficiency with phlegm-dampness(57.9%), second were dual deficiency of the spleen-kidney (26.3%); dampness-heat of whom were most common in spleen deficiency with phlegm-dampness (22.7%), second were dual deficiency of the spleen-kidney、kidney yin deficiency and dampness-heat (18.2%); blood stasis of whom were most common in dual deficiency of the spleen-kidney (50.0%), second were kidney deficiency with blood stasis(25.0%); qi stagnation of whom were most common in blood stasis due to qi stagnation (69.2%), second were dual deficiency of the spleen-kidney (17.9%); sensitiveness of whom were most common in dual deficiency of the spleen-kidney (57.1%), second were kidney deficiency with blood stasis、kidney yin deficiency and blood stasis (14.3%)8.137total cholesterol cases of this study, marginal rise of which accounted for21.2%, increase of which accounted for8.8%;139cases of triglycerides, marginal rise of which accounted for9.4%, increase of which accounted for8.6%;138cases of HDLC, increase of which accounted for37.0%;125cases of LDLC, marginal rise of which accounted for19.2%, increase of which accounted for10.4%. These results suggest that the majority of PCOS patients were Dyslipidemia.9. The logistic regression analysis between correlated factors and TCM Constitution types of PCOS:(1) Meat eater could be the protective factor of health (negative correlation), relative risk (OR)=0.149, P=0.012, confidence interval (0.033-0.661); Obesity was the risk factor of health(positive correlation), relative risk (OR)=3.488, P=0, confidence interval(1.745-6.974), which was statistically significant.(2)"LH/FSH>2" could be the protective factor of qi deficiency (negative correlation), relative risk (OR)=0.411, P=0.011, confidence interval (0.207-0.817), which was statistically significant.(3) Obesity could be the protective factor of yang deficiency (negative correlation), relative risk (OR)=0.156, P=0.003, confidence interval(0.047-0.521), which was statistically significant.(4) Acne and insulin resistance could be the protective factor of yin deficiency (negative correlation), relative risk (OR) were0.327、0.329, P were0.021、0.024, confidence interval (0.127-0.843、0.125-0.867), which were statistically significant.(5) first-degree relatives of men bald head was the risk factor of phlegm-dampness (positive correlation), relative risk (OR)=5.000, P=0.011,confidence interval(1.438-17.390), which was statistically significant.(6) Acne was the risk factor of dampness-heat (positive correlation), relative risk (OR)=3.817, P=0.035, confidence interval (1.098-13.271), which was statistically significant.(7) Fasting plasma glucose could be the protective factor of blood stasis (negative correlation), relative risk (OR)=0.118, P=0.004, confidence interval(0.027-0.508), which was statistically significant.(8) Logistic regression analysis showed that there was no factor into the regression equation of qi stagnation. It meaned that no significant difference was found in qi stagnation with six items of sex hormones, fasting plasma glucose, fasting insulin, LH/FSH>2, insulin resistance, first-degree relatives of the female menstrual disorders, first-degree relatives of men bald head, obesity, acne, hairy, acanthosis nigricans, Exercise and diet.(P>0.05)(9) LH was the risk factor of sensitiveness (positive correlation), relative risk (OR)=1.053, P=0.018, confidence interval (1.009-1.100), which was statistically significant.10. The logistic regression analysis between correlated factors and traditional Chinese medicine syndrome types of PCOS:(1) LH was the risk factor of the dual deficiency of the spleen-kidney (positive correlation), relative risk (OR)=1.046, P=0.011, confidence interval(1.010-1.082), which was statistically significant.(2) T could be the protective factor of spleen deficiency with phlegm-dampness (negative correlation), relative risk (OR)=0.638, P=0.025, confidence interval(0.430-0.946); Obesity was the risk factor of the spleen deficiency with phlegm-dampness (positive correlation), relative risk (OR)=12.255, P=0,confidence interval(5.464-27.483), which was statistically significant.(3) Logistic regression analysis showed that there was no factor into the regression equation of kidney deficiency with blood stasis and blood stasis due to qi stagnation.lt meaned that no significant difference was found in kidney deficiency with blood stasis and blood stasis due to qi stagnation with six items of sex hormones, fasting plasma glucose, fasting insulin, LH/FSH>2, insulin resistance, first-degree relatives of the female menstrual disorders, first-degree relatives of men bald head,obesity, acne, hairy, acanthosis nigricans, Exercise and diet.(P>0.05)Conclusion1. The patients who met the inclusion criteria, mainly ranged in age from21to30. The main traditional Chinese medicine syndrome type was dual deficiency of the spleen-kidney, second was kidney deficiency with blood stasis、spleen deficiency with phlegm-dampness、blood stasis due to qi stagnation; The common constitution types were health, qi deficiency, yang deficiency and qi stagnation in this case. Ranged in age from21to30were common in yang deficiency.2. Traditional Chinese medicine syndrome and TCM Constitution are not only difference but also contact. Prevention and treatment of PCOS should pay attention to the constitutional identification and the treatment of regulating constitution, actively adjust and improve the patient’s biased constitution. Controling syndromes fundamentally, so as to Cure diseases. Through the constitution Identification and treatment, we can do some preventive treatment before we are sick, prevent change if we are sick and prevent disease recurrence.3. The study showed a certain degree of correlation among the TCM Constitution types、TCM syndrome types and the clinical factors of PCOS. The bias of constitution is both internal incidence and the important factor in the development of the disease and the evolution of syndromes. Constitution can be regulated, so we can do some early intervention to the factors of the TCM constitution and syndrome types, which are effective ways and means to prevent and treat polycystic ovary syndrome. |
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