Nerve Growth Factor NGF Adenomyosis In The Expression And Relationship Between Research And Dysmenorrhea

Objective: Discussion of nerve growth factor NGF adenomyosis in the expression and the relationship with DysmenorrheaMethods:Choose from January 2007 to December 2007 in the Second Hospital of Jilin University obstetrics and gynecology because of the need to adenomyosis hysterectomy specimens(The postoperative pathologic examination confirmed adenomyosis)。Eutopic can tell lesions (including ectopic endometrial and the surrounding myometrium Adenomyoma part) of the 30 cases。Among them, 22 cases of dysmenorrhea history, no history of dysmenorrhea eight cases, Dysmenorrhea in accordance with the oral group will score VRS without dysmenorrhea group divided into eight cases, mild dysmenorrhea group seven cases, 12 cases of moderate dysmenorrhea group severe dysmenorrhea group three cases. Choose the same period due to uterine fibroids to cut the uterus except for the control group patients (postoperative pathologic examination confirmed the proliferative phase endometrium), the normal muscle wall organizations (non-muscle lesions), the 15 cases. SP by immunohistochemical staining method for organizations to detect the expression of NGF.Results: 1, NGF in the control group endometrium positive rate was 60% in the study group, the positive expression of 93.3%. Endometrial control group and research group in the endometrial expression of NGF There was a significant difference (P <0.05). 2, NGF in the control group myometrium in the positive rate was 66.7% in the study group lesions in the positive rate was 76.7%, positive cells brown granules in the cytoplasm and (or) in the cell membrane. Study Group and the control group compared to positive rates have increased though, but there was no significant difference (P> 0.05). 3, in the study group endometrial expression of NGF in both high performance expression, with the increase of pain score in the NGF in adenomyosis endometrial expression was increased gradually trend, although dysmenorrhea group and the mild group Dysmenorrhea on the expression of the positive rate decreased slightly, but expressed no significant difference (P> 0.05). 4, in the absence of NGF in the dysmenorrhea group, the positive rate was 50 percent, dysmenorrhea group NGF mild positive rate of 71.4%, moderate dysmenorrhea group NGF positive rate of 91.7%, moderate dysmenorrhea group NGF positive rate of 100 %As the pain score increased NGF positive trend was significantly higher compared with dysmenorrhea group and severe dysmenorrhea group, the positive expression of NGF was no significant difference (P <0.05).Conclusion: 1, NGF in the eutopic adenomyosis in a high expression of NGF in the eutopic adenomyosis the expression of strength may be adenomyosis in development。2, NGF adenomyosis lesions in the group with the expression of dysmenorrhea increase has been gradually strengthened。3, adenomyosis eutopic endometrial expression of strength and adenomyosis dysmenorrhea irrelevant。4, the experimental studies, it is possible for adenomyosis dysmenorrhea provide a new strategy of adenomyosis on the diagnosis and treatment of new ideas.