Expression Of NGF And PTGFR In Patients With Adenomyosis

Objective:This paper aims at detecting the differences of expression intensity of NGF and PTGFR in endometrium,ectopic endometrium,myometrial tissue and cervical tissue in different parts of the uterus of Adenomyosis.so as to provide some reference basis for the development of surgical procedures in clinical practice.Methods:The case group was composed of thirty patients who have their all uterus removed because of adenomyosis with dysmenorrhea in Department of Obstetrics and Gynecology,Chengde Central Hospital from June 2015 to May 2017.The control group was composed of thirty patients who have their all uterus removed because of adenomyosis without dysmenorrhea at the same time.Both group members were with histopathological diagnosis.Immunohistochemistry were used to detect the expression intensity of NGF and PTGFR in the endometrium,ectopic endometrium,muscular tissue and cervical tissue of the case group and the control group.SPSS21.0 software was used for statistical analysis of the data,grade data were described by case number,and Wilcoxon rank sum test of two independent samples was used for comparison between the two groups.The Friedman M test and pairwise q test were used to compare different parts of the group.Results:NGF and PTGFR were expressed to varying degrees in the endometrium,ectopic endometrium,muscular tissue and cervical tissue of the case group and the control group.The expression intensity of NGF in the endometrium of the case group was higher than that of the control group,and the difference was statistically significant(P=0.003);The expression intensity of NGF in the ectopic endometrium of the case group was higher than that of the control group,and the difference was statistically significant(P=0.001).The expression intensity of NGF in the myometrial tissue of the case group was higher than that of the control group,and the difference was statistically significant(P=0.008).The expression intensity of NGF in the corpus uteri of the case group was significantly higher than that in cervical tissue(P﹤0.001).There was no significant difference of NGF expression intensity in cervical tissue between the case group and control group(P=0.656).The expression intensity of PTGFR in the endometrium of the case group was higher than that of the control group,and the difference was statistically significant(P=0.013).The expression intensity of PTGFR in the ectopic endometrium of the case group was higher than that of the control group,and the difference was statistically significant(P=0.023).The expression intensity of PTGFR in the myometrial tissue of the case group was higher than that of the control group,and the difference was statistically significant(P=0.007).The expression intensity of PTGFR in the corpus uteri of the case group was significantly higher than that in cervical tissue(P﹤0.001).There was no significant difference of PTGFR expression intensity in cervical tissue between the case group and control group(P=0.639).Conclusion:1.The expression intensity of NGF and PTGFR in corpus uteri of patients in the case group is higher than those in the control group,which may be related to the occurrence of dysmenorrhea.2.The expression intensity of NGF and PTGFR in the corpus uteri of the case group was significantly higher than that in cervical tissue.The experimental results mentioned above could speculate that dysmenorrhea may be related to the high expression of in the corpus uteri.3.Low expression of NGF and PTGFR in cervical tissues of patients with adenomyosis dysmenorrhea was presented.And there was no significant difference between the case group and the control group.The experimental results mentioned above could speculate that the low expression of NGF and PTGFR in cervical tissues had no significant association with dysmenorrhea.4.Dysmenorrhea patients with adenomyosis have the possibility of surgery that only resecting the corpus uteri but perservating the cervix.