The Stady Of Sini Powder On Improving Gastrointestinal Motility And Its Toxicity

Dysfunctional Dyspepsia is a group of dyspepsia symptoms caused by nonorgan pathological changes. The cause of it does not definite. So far, we have beening lakeing effective remedies for curing it. There is no name about the illness in the TCM, but according its clinical symptom, it belong to the syndrome of the stomach, the stuffiness in the stomach, the scarcity desire of the dining, the gastric upset, the frequent vomiting, the spewing, the hiccup and so on. The fundamental pathogenesis of it is the liver-qistagnation the spleen-qi deficiency and the stomche-qiascending adversely. During these years, TCM has a prominent effect on Dysfunctional Dyspepsia, so we study the effect of SiNiSan of soup on the Dysfunctional Dyspepsia sharply from the ability of stomach emptying and the ability of intestines pussing on the normal Kunming rats by the coloring matter, on the stomach organize of normal SD rats.1. In the experiment, the one hundred Kuming tats, male and female, half and half, are randomly divided into five groups, gastric emptying group, Mosapride Citrate group, SiNiSan of soup(6g/kg) 15 times clinical dose, average dose(4g/kg) 10 times clinical dose, lower(2g/kg)5 times clinical dose, feeding for seven days, and fasted for 24 hours before the experiment. We study the effect of the ability of stomach emptying and the ability of intestines pussing on the Kunming rats. SiNiSan of soup and Mosapride Citrate are without obvious differences.2. The eighty Wistar Rats are randomly divided into four groups, gastric emptying group, SiNiSan soup (4g/kg) 10 times clinical dose, average(16g/kg) 40 times clinical dose, larger (32g/kg) 80 times clinical dose, gastric infusion of chitosm once a day, water free. We observe each group of rats, their activities, their meal and dejecta, injecting for twelve weeks, measuring their weight once a week, adjusting the amount of the injection based on their weight, there wasno effect on taking food, body weight, the indexes of hematology and functions of the liver and kidney and so on, as well as the coefficient of the organs. Therefore, SiNiSan is safety, less toxic traditional Chinese medicine.