The Studies On The Chemical Constituents And The Hepatic Protective Effects Of The Scorzonera Austriaca Wild

The Scorzonera austriaca Wild , perennial herbage of Compositae, is widely distributed in the northeast and northwest region of China,especially in Jilin province.It has been used in Chinese folk medicine for curing fever, carbuncle, inflammation and mastitis. In this thesis, it mains to study the chemical constituents and the hepatic protective effdcts of The Scorzonera austriaca Wild. This report mainly focuses on several aspects shown below.First, the review on chemical constituents and biological activities of Scorzonera genus and Scorzonera austriaca Wild.Second, the review on the apply on the liver-injured by CCl4 as a modelThird, the isolation of 4 compounds from Scorzonera austriaca Wild by using solvent extraction, SG column chromatography and ODS column chromatography.The structures of these compounds were elucidated by physico-chemical constants and spectroscopic analysis. They are: (Ⅰ)3-β-D-gluxopyranosyl-4(15),10(14),11(13)-triene-6,12-guaiadide;(Ⅱ)5,7 ,3′,4′- tetrahydroxyl-8-C-β-D-glucopyranosyl fravone,(Ⅲ)5 ,7 ,3′,4′-tetrahydroxyl -6-C-β-D- glucopyranosyl fravone, (Ⅳ)5 , 7 , 4′-3-hydroxy-6-C-[β-D-xylose- ( 1→2 ) ]-β-D- glucopyranosyl fravone。Further more, using the liver-injured mice induced by carbon tetrachloride as a model.the hepatic protecctive effects of the extracts of the Scorzonera austriaca Wild were studied.According to the relative analysis of medical dfficiency in the model group,the medicine group,medicine-positive group,we found the extracts had difference (P<0.05) The results demonstrared that it plays an apparent and relialbe role of curing the carbon thtrachloride-inducde acute hepatic injury.