| Objective :in clinical practice,"wei kang ping fried"has a great effect in treating functional dyspepsia of stagnaTion of liver-QI with deficiency of the spleen,this investigation is to research for therapeutic principle in treating functional dyspepsia(which is abbreviated FD below )with the traditional Chinese medicine,Through investigating the change of nitro- gen monoxidum,acetylcholine,motilin of FD sufferer and FD big rat model and in big rat model stomach organization in wei kang ping fried。To investigate wei kang ping fried a treatment function an indigestion mechanism,For raising clinical curative effect to provide a certain theories basis。1 experiment investigation The method of build the mold accordings to cultural heritage to with tail between legs stimulate a method,and combine an anomaly to feed to keep the impaired digestion big rat model of the replication function ,Have impaired digestion the big rat to the function to random be divided into a model set,the set of DomperiDone,big amount of set,small amount of set, big amount of set,each 8:8 normally big rats is blank matched control(the brief name"blank set")。random be divided into a model set, the set of Domperidone,small amount of set,big amount of set, each 8:8 normally big rats is blank matched control(the brief name"blank set")s。Does the set of Domperidone,give the aqua of Domperidone infuse stomach. distilled water which infuse to take an equal physical volume of model set and blank set.After use medicine for 2 weeks break a head to sentence to death animal,get material,measure gastric weight.Examine serum in and stomach organization evenly strach medium the content of NO,MTL and AchE。2 Clinical investigation according the standard diagnosis of the function ofⅡassociation in Rome establishment standard from my section October, 2005 to the out-patient service case in October,2006,Select is tried a case 40 Combine the basis be clinical to express for Among them, male's13, female 27, the age is 18~69 years old, equally 35 years old;The course of illness is 1~2 years。Is divided into 3 sets according to the random principle,namely big amount of set,small amount of set, the set of DomperiDone,Small amount of set the patient take orally theWei Kang Ping fried,each take once before the rice sooner or later,everyday 1:The big amount of set is small amount of set of 200%,Ding Mao set does the patient take orally DompEridone;Everyday 2 times。Cure the period forbids to use any other stomach and intestines motive medicine。Result :The model set with tail between legs stimulates in a row,and combine an anomaly to feed to keep after 2 weeks, the big rat appears a hair color ash dark, lose sheen, the spirit easily arouses to ask for,fidgety irascibility,the weight ease, move bowels to not too take shape and present one obvious of impaired digestion symptom,at the cultural heritage report way consistent , certificate function indigestion of model establishment success。1 Each index sign influences big rat modelModel group(8.88) and blank group(28.06) mutually compare , Check the X2 boundary value form get(0.025< p<0.05),Can think that the row of blank group gets empty rate raising at the model group,Big dosagegroup(20.31)and model group (8.88) compare,(0.25< p<0.5) Still can't think that two group of rates with empty rows have difference;Small doSa Gegroup (30.81) and model group (8.88) compAre(0.005 < p<0.01), Can think a small amount of line up of set empty the rate Gao is at the model set Model set(8.88) with the set of Domperidone (14.68) compare(0.9< p<0.95), Still can't think that two sets of rates with empty rows have difference;The set of Domperidone (14.68) and blank set(28.06) compare(0.05< p<0.1),Still can't think that two sets of rates with empty rows have significant difference; Big amount of set(20.31) with the set of Domperidone (14.68) compare,(0.1< p<0.25),Still can't think that two sets of rates with empty rows have difference;Big amount of set(20.31) and small dosagegroup (30 . 81) compare(0.5< p<0.75), Have no covariance to learn meaning。1.2 To the influence of the AchE content in the serumThe AchE content and the blank set in the model set(6.77±0.80) big rat serum(16.94±4.63)compare to obviously lower;( p<0.05) After interfere,small amount of the set(15.74±4.53) be obviously high at the model set(6.77±0.8) ;( p<0.05)Big amount of set(10.01±1.68) with to compare with model set(6.77±0.80),the set of Domperidone (10.24±1.80) also obviously goes up(p<0.05), Small amount of set(15.74±4.53) with big amount of set(10.01±1.68) with the set of Domperidone (10.24±1.80) has already shown significant difference;( p<0.05)But big amount of set(10.01±1.68) with the set of Domperidone (10.24±1.80) didn't show significant difference ( p>0.05)。1.3 To the influence of the NO content in the serumThe NO content and the blank set(32.53±6.30) compares to obviously go up in the model set(69.75±12.74) big rat serum,( p<0.05),After interfere,big amountof set(45.86±8.10) small amount of set(35.57±5.86) and the set of Domperidone (45.40±7.4) be obviously low at the model set(69.75±12.74);( p<0.05) But the big measure(45.86±8.10) a set with the set of Domperidone (47.52±9.59) compared and don't show significant difference( p>0.05) Small amount of the set(40.94±5.29)be obviously low in big amount of set(45.86±8.10) with the set of Domperidone(45.86±8.10)( p<0.05)。1.4 To the MTL influence in the serumThe MTL content is obviously low at the blank set(460.74±29.89) in the big rat serum;(p<0.05) After interfere,big amount of set(412.34±1.40) with to compare with model set(373.96±25.27),the set of Domperidone (413.33±12.04) obviously goes up;( p<0.05) Small amount of the set(455.86±18.25) is bigger amount of set(412.35±1.40) with the set of Domperidone (413.33±12.04) obviously goes up;( p<0.05) Big amount of set(412.35±1.40) with the set of Domperidone (413.33±12.04) didn't show signifcant difference( p>0.05)。1.5 The stomach organizes in the NO influenceModel set(4.08±0.23) big rat stomach the NO content obviously is obviously step up the blank set (2.73±0.15) in the middle of the organization;( p<0.05); After interfere, to compare with model set, the big amount of set(3.40±0.28), small amount of set(3.45±0.24) obviously lowers, ( p<0.05) And two sets ofs didn't show significant difference ;( p>0.05)The set of Domperidone (3.68±0.23) and model set(4.08±0.23) compare to obviously lower;( p<0.05) :Big amount of does the set(3.40±0.28) compare with small amount of set(3.45±0.24) the set of Domperidone (3.68±023) obviously lowers;( p<0.05) Big amount of set with small amount of be the set better than the set of Domperidone;Big amount of the set(3.40±0.28) have no with small amount of set(3.45±0.24) to show significant difference。( p>0.05)1.6 The stomach organizes in the AchE influenceModel set(2.63±0.34) big rat stomach to compare with blank set , the AchE content in the organization compare(4.41±0.74) to obviously lower ; ( p<0.05) After interfere,to compare with model set(2.63±0.34), the small amount of set(4.27±0.61) obviously goes up;( p<0.05) Big amount of set(3.58±0.53),The set of Domperidone (3.68±0.23) and model set(2.63±0.34) also obviously go up;( p<0.005)The small amount of set surpass big amount of set with the set of Domperidone。2 Each index sign has impaired digestion the sufferer's influence to the function2.1 Influence the NO(theμmol/L) in the serum With the set of Domperidone (64.975±17.34) compare, Wei Kang Ping fried set(36.996±6.01) sufferer the NO content obviously lowers in the middle of the serum;( p<0.05)The of two sets of sufferer's teams has already shown significant difference.( p<0.05)2.2Influence the AchE(theμmol/ml) in the serum Wei Kang Ping fried set(9.654±2.3) sufferer the AchE content in the serum with the set of Domperidone (6.029±1.9) compare to obviously go up;( p<0.05)The of two sets of sufferer's teams has already shown significant difference.( p<0.05)2.3Influence the MTL(pg/ml) in the serumWith the set of Domperidone (64.975±17.34) compare, Wei Kang Ping fried set(347.064±88.84) sufferer the NO content obviously lowers in the middle of the serum;( p<0.05)The of two sets of sufferer's teams has already shown significant difference( p<0.05). Conclusion:1 Pass an experiment, confirm guide in"the Shu liver Jian Pi and stomach method"principle under choose to use of the stomach Kang be even fried have to obviously go up the AchE level in the serum, and regulate secrete of free radicals NO, and lower NO level, attain to regulate stomach and intestines sport and help the stomach to line up an empty function thus。2 In order to further confirm that the Wei Kang Ping fried can secrete through an influence MTL this experiment, and make the MTL go up, improve FD symptom thus, and established theories and test foundation for the function which studies stomach and intestines hormone in the FD the outbreak the mechanism。3 The stomach Kang is even fried to liver Yu Pi falsely the type FD have good curative effect, can promote the stomach row empty ability, the exaltation immunity function, but because of FD is chronic disease, and cause of disease complications, is various cause of diseases with the result that, have to from various, have another angle is all-directions of synthesize essence that know function's indigestion, and its treatment project.Because research budget and experiment condition limit, this experiment is just from the oxygen free radicals, stomach and intestines hormone, the nerve passed quality a few aspects to inquiry into"the Shu liver Jian Pi and stomach method"a treatment liver Yu Pi falsely type ability indigestion function mechanism, also need further from other aspect studies with perfect。...
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