Study On The Effects Of Biocoloid And Gatifloxacin On Preventing Tendon Adhesion And Local Infection

Objectives: To evaluate the effects of fibrin tissue adhesive and gatifloxacinon preventing adhesion and local infection of tendon after tenorrhaphy.,toobserve recovery of hand function. Methods: Twelve patients(21 flexortendons) with flexor tendon injury, who were treated at the Department ofOrthopeadic Surgery, The Affiliated Haici Medical Group of QingdaoUniversity Medical Colloge, were observed from January 2006 to October2006. When the injury of flexor tendon inⅡ,Ⅲ,ⅣandⅤareas of handsand forearms were spliced with the modified Kessler tendinosuture, thefibrin tissue adhesive and gatifloxacin were injected into the sheaths of theruptured tendons or spurted at the point of suture of tendon. And therehabilitation of the injury fingers was applied earlier under the protection ofthe externai fixation. The other 13 patients with 23 flexor tendons weretreated with the same methods without using the fibrin tissue adhesive andgatifloxacin served as controls. All the patients of both groups were followedup at the second-the tenth month after operation. According to the standardsthe function of injured hands and effects were detected with total activemovement (TAM) according to the standard of plerosis of tendon of handsdesigned by hand surgery association of Chinese Medical Association.Results: Among 12 patients with 21 tendons in the fibrin tissue adhesive andgatifloxacin group, 13 patients with 23 tendons in the control group werefollowed up with the follow-up rate of 100%. The duration of follow up wasfrom 2 months to 10 months. 21 tendons in the fibrin tissue adhesive andgatifloxacin group, were followed up, in which 19 tendons had good effectwith the excellent and good rate of 90.48%. 23 tendons in the control groupwere followed up, in which 12 tendons hand good effect with the excellentand good rate of 52.17%. There was significant difference between the twogroups (x~2=7.7365, p＜0.05). Conclusion: the fibrin tissue adhesive andgatifloxacin can prevent and reduce the tendon adhesive and local infectionafter operation, and effectively accelerate the functional rehabilitation of injured hands in the tendinosuture inⅡ,Ⅲ,ⅣandⅤareas of hands andforearms.