Experimental Study On Prevention And Cure Glucocorticoid-Induced Avascular Necrosis Of Femoral Head By The Hugu-Electuary

Objective: The discussion protects the bone powder prevention treatment Glucocorticoid-induced avascularnecrosis of femoral head the function mechanism.Methods: Stochastically divides into 4 groups 32 Japanese big ear white rabbit, each group of 8. I group is the blank group, II group is the model group, III group for medicine comparison group, IV group for powder group. I group of each only each week buttocks muscle injections physiological saline. II every goes through an ear set, III set with the set IV predestined relationship intravenous horse serum 10 ml/kg , gaps 2 cycles, continuous two days injection horses serum is respectively once inferior according to 5 ml/kg dosage, gap 2 cycles, inject acetic acid respectively according to 20 mg/kg , 30 mg/kg , 40 mg/kg abdominal cavities splashing 3 time of Nisonglong (inject 1 time every 3 day), simultaneous injecting hormone forms an animal respectively using different method to irrigate the stomach respectively. The period forms rabbit respectively buttocks muscle injection penicillin 80,000 u/ gods of the earth resist infection. 5 cycle queens put all animals to death.Result: The Hugu-electuary make the empty space bone get bogged down bending it into a number cutting down (P<0.05), the blood vessel number and pith inner hematopoiesis organization increase by (P<0.05). The immune group spends finally demonstrating expressing protecting the bone electuary may improve VEGF in blood vessel bast and the pulp cavity (P <0.05).Conclusion: The Hugu-electuary may rivalry the inhibitory action of hormone to VEGF, and Indirect urge the VEGF expressing to strengthen, make the new blood vessel come into being increasing by it. Can maintain or the increase stock bone blood supplies, to cause the stock bone to lack the courage and uprightness necrosis the symptom to be able to alleviate, thus preventing and controlling GANFH.