Experimental Study Of Chinese Medicine Prevention And Treatment Of Diabetic Osteoporosis

IAbstractl Objective To explore the regulating mechanism of Bu sheng Zhuang Gu Capsules (BC) on bone metabolism and bone remodeling of Diabetic Osteoporosis (DO) rats models. Methods Established DM rats models by in- troperitoneal injection of Alloxan. Trended the diabetic rats with condensed liquor of BC and Calcium Carbonate Tablets + Alpha D3(C+A) respectively through tube feeding, and Metformin Hydrochloride Tablets (M.H.) as basic remedy meanwhile. Observed the influence of different medicines on following parameters: diabetic general condition, bone mineral density (BMD), bone metabolism biochemical criterion, bone biomechanical property, bone histomorphometry and hemorheology, content of advanced ghycosylation end products (AGES) in bone collagen, c-fos expression of osteoblasts as well. Results The experimental DM rats showed apparently abnormal on parameters stated above. BMD of them are significantly lower than normal group. After the therapy of BC, the abnormal condition relieved markedly. And the comprehensive action of BC was better than that of west medicines. Conclusion These results suggested that diabetic rats had clearly osteopenia and osteoporosis. BC can modulate effectively the bone metabolism and the bone remodeling of DO rats models through many ways and many links.