| Objective: To observe the clinical effect of TaoRenHongHuaJian andYanhusuo alkaloid on ventricular premature systole of coronary heartdisease and explore its mechanism of effect.Methods: Sixty patients of ventricular premature systole were dividedrandomly into treatment group(30 cases) and control group(30 cases).Conventional medical therapy was given to the both groups and thetreatment group received additional Chinese medicinal formulaeTaorenhonghuajian treatment. The changes of clinical symptoms andtherapeutic effect of premature systole in all the patients were observedbefore and after treatment. Sixty SD rats were divided randomly into blankcontrol group, sham operation group, classics fore treatment group andgroup of myocardial ischemia reperfusion model with Yanhusuo alkaloidhigh, moderate, minimal dose. To observe the impact of differentmanipulate ways and all the different dosage on the rats.Results: In the treatment group, the total effective rate of melioratingsyndrome and some symptoms of TCM were significantly better than thoseof the control group(P＜0.05) while therapeutic effect of prematuresystole did not show the difference after two weeks' treatment, animaltest show Yanhusuo alkaloid can decrease the rate of arrhythmia in ratmodel with myocardial ischemia reperfusion and reveal Yanhusuo alkaloidhave some protection to myocardial damage.Conclusion: TaoRenHongHuaJian can improve syndrome of TCM on treatingventricular premature systole of coronary heart disease, Yanhusuoalkaloid can decrease the rate of arrhythmia in rat model with myocardialischemia reperfusion due to some protection to myocardial damage.
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