Gene Polymorphism Of Myeloperoxidase And Genetic Susceptibility To Essential Hypertension

BACKGROUND & OBJECTIVE: A-463 bp G/A polymorphism is located in the promoter region of myeloperoxidase(MPO)gene was found to be associated with bioavailability of NO. However, its association with Essential Hypertension remained unclear. The aim of this study was designed to explore this association in Chinese population.METHODS: MPO genotypes' in 107 cases of essential hypertension and 97 persons of healthy control were detected using PCR-restriction fragment length polymorphism assay(PCR-RFLP) in a case-control molecular epidemiology study. The association between this gene polymorphism and the risk of Essential Hypertension in Chinese population was examined through comparing odds ratio (OR)and 95% confidence interval (CI) between two groups.RESULTS: In healthy control group, the frequencies of persons carrying G/G, G/A, and A/A genotypes were 56.7% , 40.2% , and 3.1%, respectively . In Essential Hypertension group , the frequencies of the persons carrying above three genotypes were 70.1% , 29.0% , and 0.9% , respectively. There was significant diference of the frequencies of G/A genotype between two groups (P <0. 05), the risk of Essential Hypertension for person carrying G/G genotype was 1.79 fold of the persons carrying at least one A allele (95% Cl 1.005～3.186).CONCLUSION : MPO gene polymorphism was associated with susceptibility of Essential Hypertension in Chinese population. The risk of Essential Hypertension was decreased in the persons carrying allele A.