| Objective: At present Pancreatic cancer (PC) is one of the most serious disease in the preceding cancer of human body.Prevalence rate of it is shown rising worldwile, Prognosis is extremely poor since diagnosis is usually late due to lack of symptoms.We endeavor to approach PC's several clinical features ,such as its initial and main symptoms, factors which affect these sumptoms ,its misdiagnosis and detection rates by imaging tests etc through retrospective analysis of 110 cases of PC.Materials and methods: The 110 cases of PC from January 2000 to December 2006 in the First Hospital of Jilin University which were diagnosed denifinitely and have complete data were analyzed retrogradely according to the etiology ,clinical manifestations, diagnosis and treatment methods.Results: 1. The morbidity rate of male versus female was 2.34:1, and medium age was 56.7±15.5. The incidence of PC increases wwith age-growth, 94.34% patients was less than 40 years- old. 70% PC cases had their tumors in the head of pancereas.2. Epidemiology: The frequent etiological factor were as follows: excessive smoking (25cases),heavy alcohol drinking (14cases),disease of biliary tract or operation on it (19cases),diabetes mellitus history (12cases),chronic pancreatitis (3cases),familial history (2cases).3. Clinical data:①Early clinical situation had no specificness. Abdominal pain (53.64%),epigastric discomfort (16.34%) and jaundices (10.00%) were the most initial symptoms; jaundices (60.00%),abdominal pain (58.18%) and weight loss (30.00%) were the most main symptoms;②The tumor location dramatically affected cardinal symptoms of PC, Abdominal pain was showed when tumors located in body and tail or all of pancreas, but Jaundice was significant when tumors located in the head of pancreas.③Jaundice was a major appearance among male (male to female: 3/1); however, nausea or emesis was common aomong female (male to female: 1/2).④70.24% PC cases have found tumor diaplace. Liver (30.28%), abdominal membrance (20.86%) were the most common.⑤Laboratory examination: The positive rate of CA19-9 was 66.67%, other serum tumor maker: CEA 26.67%,CA125 27.78%,AFP 7.50%.CA 19-9 had no specificness to diagnose of PC case.⑥Imaging examination: The positive rate of enhancement computer tomography,ultrasonography,computer tomography and mangnetic resonance was 96.88%,90.75%,87.84% and 87.50% respectively.4. Misdiagnosis condition: 48 cases were misdiagnosised in the study, the misdiagnosis rate of PC approximated to 43.64%; diseases of misdiagnosis were belong to 10 categories, in which the most common diseases were gastritis and duodenitis,peptic ulcer,virus hepatitis,cholelithiasis and chronic pancreatitis.Conclusion: 1. The incidence of PC increase which increaseswith age-growth, and male versus female is 1.27:1, the on-set peak happended in the 60-69 year-old. 70% PC cases had their tumors in the head of pancereas. 2. Abdominal pain,epigastric discomfort and jaundices were the most initial symptoms; jaundices,abdominal pain,weight loss were the most main symptoms. 3. The tumor location dramatically affected cardinal symptoms of PC, Abdominal pain was showed when tumors located in body and tail or all of pancreas, but Jaundice was significant when tumors located in the head of pancreas.4. Clinical symptom of PC is associated as sexuality. Jaundice was a major appearance among male. however, nausea or emesis was common aomong female. 5. Laboratory examination had no specificness. The positive rate of CA19-9 was at low-level, ultrasonography and computed tomography had satisfactory detection rates to PC; enhancement computer tomography was done according to patient's condition; 6. Early clinical situation had no specificness. the misdiagnosis rate of PC approximated to 43.64%; diseases of misdiagnosis were belong to 10 categories,in which the most common diseases were gastritis and duodenitis,peptic ulcer,virus hepatitis,cholelithiasis and chronic pancreatitis. Abdominal pain and epigastric discomfort were easy to mislead diagnosis, but jaundices were helpful.7. Improving radical resection rate of PC is basis on the early diagnosis. the early diagnosis is the key to reduce the rate of misdiagnosis and missed diagnosis.
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