Analysis Of Clinical Characteristics And Prognostic Factors Of Pancreatic Cancer (137 Cases Attached)

Objective:To retrospectively analyze the clinical data and survival time of 137 patients diagnosed with pancreatic ductal adenocarcinoma in our hospital,to analyze the clinical characteristics and prognostic factors,and to obtain the clinical features of the pancreatic ductal adenocarcinoma Risk factors and protective factors,and thus have a guiding significance for the diagnosis,survival prediction,and treatment of clinical pancreatic cancer patients.Methods:The clinical data and follow-up of 137 patients with pancreatic cancer whose pathology was diagnosed as ductal adenocarcinoma from our Hospital from July 2014 to July 2019 were reviewed.Sexual analysis.SPSS 20.0 statistical analysis software was used.The t-test was used for measurement data conforming to normal distribution between groups,and chi-square test was used for count data and grade data.The Kaplan-Meier method was used to calculate the survival rate,and the comparison of the survival rate curve was by the Log-Rank test.Kaplan-Meier method was used for single factor analysis,and COX proportional hazards model was used for multivariate regression analysis of each factor affecting prognosis.P<0.05 was considered statistically significant.Results:The median survival time for all patients with pancreatic cancer was 8.5 months,and the average survival time was 14.4 months.The risk factors for the prognosis of pancreatic cancer obtained by single factor analysis were:the age of onset is greater than 60 years,and the tumor stage is ?-?,No surgery,degree of differentiation is poorly differentiated or undifferentiated;lymph node metastasis>3,CA199>1000U/ml,CA125>35U/ml,CA15-3>28U/ml,positive surgical margin,Ki-67>50%And new-onset diabetes.In addition,not undergoing chemotherapy is a risk factor for patients with pancreatic cancer surgery.Multivariate analysis showed that stage ? or stage ? and smoking were the risk factors for pancreatic cancer(p=0.005,p=0.000,p=0.020),and the relative risk values were 1.658,2.420,3.849,respectively;for surgery In patients,poorly differentiated and undifferentiated(p=0.001)and the number of lymph node metastases greater than 3(p=0.011)are the prognostic risk factors for patients with pancreatic cancer surgery,and the relative risk values are 5.216 and 2.488,respectively.Chemotherapy and surgery are protective factors for the prognosis of pancreatic cancer patients(p=0.000,p=0.004),and their relative risk values are 0.576 and 0.462,respectively.Conclusion:Pancreatic cancer has the clinical characteristics of strong occultity and poor prognosis.The incidence of males is slightly more than that of females.The sex ratio is 1.4:1.The age is more than 50-70 years old.At the initial diagnosis,abdominal pain,abdominal distension,jaundice,and increased blood sugar As the first symptom,the head and neck area of the tumor is more than the tail of the body,the ratio is 1.6:1,more than 60%of patients are diagnosed at stage ?-?,and the median survival time is 8.5 months,of which 1 year,2 years,3 The annual cumulative survival rates were 41.6%,16.8%,and 8.8%,respectively.Patients with diabetes have a higher proportion of tumors at the tail of the body,a larger proportion of stage ? tumors,a higher CEA value,and a larger tumor maximum diameter.However,it cannot be proved whether diabetes is a risk factor for the prognosis of pancreatic cancer patients.After data analysis,the prognostic risk factors for pancreatic cancer are:age of onset is greater than 60 years old,tumor stage ?-?,no surgery,the degree of differentiation is poorly differentiated or undifferentiated,lymph node metastasis>3,CA199>1000U/ml,CA125>35U/ml,CA15-3>28U/ml,positive surgical margin,Ki-67>50%,new diabetes,no chemotherapy.Chemotherapy and surgery are protective factors for the prognosis of pancreatic cancer patients(p=0.000,p=0.004),and their relative risk values are 0.576 and 0.462,respectively.Patients with early symptoms of abdominal pain have a worse prognosis.The median survival time of pancreatic cancer patients in the TCM treatment group is longer than that in the group without TCM treatment,but this study cannot prove that TCM treatment is beneficial to the prognosis of pancreatic cancer patients.