| BACKGROUND & AIMPancreatic cancer is one of the most common malignant digestive tumours.It's morbidity is increasing year by year. Pancreatic cancer has a hiding beginning, a fast progression and a extremely bad progression. And because of the anatomical position and it's complicated function, the Early diagnosis and the difficulty of curing this tumor are big problems for the pancreatic cancer. This article is to explore the clinical characteristics of the patients of pancreatic cancer in our hospital. MATERIAL & METHODS318 cases of pancreatic cancer were reviewed and analyzed retrospectively, which were from the No 1 affiliated hospital of Zhejiang University during Jan 1993 to May 2006. And to use the software of Access2003 and SPSS13.0 for statistics. RESULTPancreatic cancer is 1.89 times more prevalent in men than women. It more occurs in older age-group,80% of the patients were older than 50. The positions of tumours in 318 cases were different,including 230 cases (72.3%) in the head,75 cases (23.6%) in the body and tail ,and 13 cases(4.1 %)in the whole . 34 of 318 cases (10.7 %) were smokers,and 29 cases (9.1 %) were drinkers.24 cases (7.5%) had a disease of biliary tract or had an Operation on biliary tract. 37 cases (11.6%) had diabetesmellitus and 7 cases (2.2%)had pancreatitis. The clinical symptoms and signs were multiplicity,including abdominal pain (52.5%), jaundice (36.5%),epigastric distention (30.5%), weight loss (28.3%), up abdominal tenderness (18.9%) and hepatomegaly (29.0%), which were common. The positive rate for diagnosing with CA199 B-ultrasonograph, CT, and MRI were 81.3%, 82.1%, 83.9% ,and 90% respectively. It was 95.7%, 93.3% respectively when we combinated of CA199 and CA125 or B-ultrasonograph. There were cases whom were interviewed by phone, respectively with 1-year and 5-year survival rate consisting of 58.9% and 12.2% in the radical excision group, 39.3% and 1.2% in the un-radical excision group and 30.1% and 1.0% in the none surgery group. CONCLUSIONS1. Inherited genetic factors and environmental factors are known as the main causes of pancreatic cancer. There are no specific early symptoms or sign of pancreatic cancer. And ti is difficult for early diagnosis and curing this tumur.2. Compared with CA199 alone, combination of CA199 and CA125 may increase the positive rate for diagnosis. At the same time, combination of CA199 and some imaging examinations like B-ultrasonograph, CT, MRI,DSA and so on may also increase the positive rate for diagnosis.3. The normal therapy principle is a combined therapy that radical excision is use for the main treatment with some adjuvant treatments including radiotherapy, chemotherapy, or neoadjuvant chemotherapy .The radical excision may extend long term survival and may increace the 1 year or 5 year survival rate, and It is the most uesful therapy for pancreatic cancer nowdays.The palliative surgery may advances the life quality, but could not increase the long term survival.
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