To Study The P16～(INK4A) In Cervical Lesions

Cervical cancer is one of the most common cancer among women worldwide, and nearly 500 000 woman developing the disease each year, with nearly 80% of cases arising in less developed countries,most case occur in less developed countries where no effective screening systems are available.and it is the principle cancer among women in most developing countries.Cervical cancer is considered a preventable by regular screening by exfoliative cytology screening identifies dyplastic and neoplastic epithelial of cervix, which conveys a risk of development into invasive carcinoma; these lesions can then be removed or ablated. The important role of human papillomaviruses (HPV) infection in cervical carcinogenesis is now well established. Indeed, HPV infection has been detected in almost all preneoplastic and neoplastic lesions of the cervix.HPV 16 and 18 have two transcriptional units. The effective method for HPV test by HC-II,but it is limited in extensive application because of high price. So search about a biomarker for cervical cancer is important.p16^INK4A is a tumor suppressor protein that inhibits the function of cdK4 and cdK6, which in turn regulate the G1 checkpoint. CDK/cyclin-D phosphorylate the retinoblastoma protein (pRb), resulting in a conformational change, with the release of E2F from pRb. Thus, inactivation of either p16^INK4A or Rb function allows the cell to enter the S phase after only a brief pause at the Gl checkpoint.This article aim to investigate whether the P16^INK4A can be a significant biomarker indiagnosis of cervical cancer and precancerous.ASC (Atypical Squamous Cells) is a class for reporting cervical cytopathologic diagnoses. A report of ASC is always confusing or painful to the clinician, as histological correlate of this diagnosis is wide, ranging from a totally normal cervix mucosa to infiltrating carcinoma.