The Relative Study Among Pancreatic Beta-cell Function, Insulin Resistance And Endothelial Function In Newly Diagnosed Patients And The Evaluation Of Effect Of Intensive Insulin Treatment

Objective: Type 2 diabetes mellitus (T2DM) is considered as a slowly progressive disease. Pancreatic beta-cell dysfunction and insulin resistance (IR) are the determinant of type 2 diabetes mellitus. It is remains controversial that whether pancreatic beta-cell dysfunction or insulin resistance triggers the genesis of type 2 diabetes mellitus and mainly contributes to blood glucose increase. The recent researches have showed that early intensive insulin treatment can obviously improve beta-cell function and make the blood glucose well controlled in newly diagnosed type 2 diabetic patients, which can delay the progress of diabetes. However, blood glucose is not well controlled in some patients after intensive insulin treatment, and the United Kingdom Prospective Study demonstrated that after intensive insulin treatment in some patients, pancreatic beta-cell function deterioration was not held back and chronic complication was not prevented. From these researches, it is shown that not all newly diagnosed type 2 diabetic patients are suitable to early intensive insulin treatment. How about the beta-cell function and insulin...