1.Transient Intensive Insulin Therapy Improves Pancreatic Beta-cell Function In Newly Diagnosed Type 2 Diabetic Patients 2.The Concentration Of Free Fatty Acids And Its Correlation Analysis In Patients With Polycystic Ovarian Syndrome

Objective: To study the effect of transient intensive insulin therapy on glycemic control and beta-cell function in newly diagnosed type 2 diabetic patients. Methods: 25 Newly diagnosed type 2 diabetic patients were treated by multiple daily injection (MDI) for 2 weeks and their beta-cell function were assessed by intravenous glucose tolerance test and arginine stimulation test. Plasma glucose ,the first-phase insulin secretion stimulated by glucose and arginine , the ratio of fasting insulin and fasting plasma glucose (FINS/FPG) , Homa-β,Homa-IR and insulin sensitive index(ISI)before and after the insulin treatment were analysed and compared.After the treatment,all patients were followed up for their glycemic control. Results: At the end,18 patients completed the study and all the patients obtained perfect glycemic control. FPG and 2-hours post prandial glucose (2hPG) decreased significantly(P<0.05)after 2-weeks intensive insulin therapy. The first-phase insulin secretion stimulated by glucose , the mean AUC of insulin , Homa-β and the ratio of FINS/FPG increased significantly (P<0.05).Insulin sensitivity(Homa-IR and ISI)was considerably improved after the treatment.There was no significant change of the first-phase insulin secretion stimulated by arginine (P=0.7.During 3 months followed-up, four patients kept perfect glycemic control only with diet and exercise, and for others antihyperglycemic drugs were needed. Conclusion: Transient intensive insulin therapy in the early phase of type 2 diabetes can effectively control hyperglycemia and improve the first-phase insulin secretion stimulated by glucose, but has no effect on the first-phase insulin secretion stimulated by arginine.