Studying Of Relationship Between Essential Hypertension TCM Syndromes And Classification Of Cardiovascular Danger Factors

Objective:Discuss the Correlation between TCM syndromes of essential hypertension, and classification of cardiovascular danger factors, in order to research differentiation between TCM syndromes of EH. And supply objective index for syndrome differentiation of TCM in EH.Materials and methods:176 cases (male 80, female 96, mean age 67. 93 ± 0. 81 years) with EH were selected as research subjects. About indexes were compaired with 20 cases of normal people. These cases were classified into four groups according to liver-fire hyperactivity, yin deficiency and yang hyperactivity, excessive phlegm-dampness, yin-yang deficiency. All case were observed Lever of blood pressure (BP) , age, fasting total cholesterol(TC) , triglyceride (TG), highdensity lipoprotein cholesterol (HDL-C) , low density lipoprotein cholesterol (LDL-C), OGTT,Creatinine(Cr), urinary albumin excretion(UAE). All cases were observed by Color Doppler ultrasonography and echocardiography. To find the character of hypertension and syndrome in traditional Chinese medicine through relationship between syndrome differentiation typing and classification of cardiovascular danger factors.Results:1. The comparison among different syndromes of hypertension shows that the increase of LDL-C is most obvious in the syndrome of excessive phlegm-dampness, having difference compared with the other three groups.2. The comparison among different syndromes of hypertension shows that the ratio of MS is most obvious in the syndrome of excessive phlegm-dampness, having obvious difference compared with the other three groups.3. The comparison among different syndromes of hypertension shows that the intima-media thickness(IMT) and plaque number is most obvious in the syndrome of excessive phlegm-dampness, having obvious difference compared with the other three groups.4. The comparison among different syndromes of hypertension shows that the incidence of left ventricular hypertrophy (LVH) is most obvious in the syndrome of yin-yang deficiency, having obvious difference compared with the other three groups.5. The comparison among different syndromes of hypertension shows that the increase of Cr and UEA is most obvious in the syndrome of yin-yang deficiency, having obvious difference compared with the other three groups.6. The comparison among different syndromes of hypertension shows that the incidence of coronary heart disease (CHD) , ischemic cerebrovascular disease(ICD) and TIA is most obvious in the syndrome of excessive phlegm-dampness, having obvious difference compared with the other three groups and the incidence of congestive heart failure (CHF) and chronic renal failure (CRF) is most obvious in the syndrome of yin-yang deficiency, having obvious difference compared with the other three groupsConclusion:1. The case of EH with increase of LDL—C or with MS can be applied as the subjective index for the syndrome of excessive phlegm-dampness.2. The case of EH with AS can be applied as the subjective index for the syndrome of excessive phlegm-dampness.3. The increase of Cr or UEA can be applied as the subjective index for the syndrome of yin-yang deficiency.4. The case of EH with CHF can be applied as the subjective index for the syndrome of yin-yang deficiency.5. Compare to the syndrome of liver-fire hyperactivity and yin deficiency and yang hyperactivity, the syndrome of excessive phlegm-dampness and yin-yang deficiency have more dangerous and more complications, the syndrome of liver-fire hyperactivity and yin deficiency and yang hyperactivity almost in the former of course, and the syndrome of excessive phlegm-dampness and yin-yang deficiency almost in the later of course .6. Treate the case of liver-fire hyperactivity and yin deficiency and yang hyperactivity, not only control BP, but control cardiovascular danger factors and prevent target organ damage (TOD). Treat the case of excessive phlegm-dampness, we must control the lever of blood glucose and LDL-C, prevent or delay AS. Treate the case of yin-yang deficiency, we must ameliorate LVH and prevent decreasing function of heart and kidney.