Study On The Clinical Relativity Between Carotid Intima-media Thickness Of Essential Hypertension Patients And Cardiovascular Risk Factor

Objective:Through ultrasonography of carotid intima-media thickness(IMT) in patients with essential hypertension,to analyze the relativity between carotid IMT and some cardiovascular risk factors,such as Systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),body mass index(BMI),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),C-reative protein(CRP),etal.in order to provide proof of prevention and cure of clinical EH patients' AS.Methods:To select a total of 126 subjects of hyperpietic applying on Doppler ultrasound instrument,and to mensurate carotid IMT.Meanwhile,to measure blood pressure,FBG,TC,TG,HDL-C,LDL-C,stature,avoirdupois,kummerbund,CRP of patients,which,then,be classified into IMT natural group(IMT＜0.9mm) and IMT incrassation group(IMT＞0.9mm) by the thickness of carotid IMT.To compare two groups of SBP,DBP,FBG,TC,TG,HDL-C,LDL-C,RMI,CRP,and to compare the frequencies distribution of abnormal cardiovascular risk factors between two groups, and to give different levels of EH patients and compare different levels of EH patients with IMT and CRP.Results:1.The different levels of cardiovascular risk factor between two groups: comparing IMT incrassation group with IMT normal group,SBP has been heightened clearly with a sense of statistics(p＜0.05),while the differences of two groups in DBP, BMI,WC,HDL-C has no meaning in statistics(p＞0.05).FBG,TC,TG,LDL-C has a sense in statistics with a level of a=0.05,and,carotid IMT has been increased while the level of blood pressure,blood sugar,TC,TG,LDL-C was heightened.2.The difference between different levels of hyperpietic and IMT,CRP:the result indicated that the higher of level of hyperpietic,the thicker of IMT and the higher of CRP.3.The frequencies distribution of abnormal cardiovascular risk factors among two groups:As table 3 showed,analyzied by chi-square test,The percentage of overweight,abdominal fatty,high blood TG,low blood HDL-L were compared.There were no statistical significant(P＞0.05).But the percentage of hypertention,diabetes, high blood TC,high blood LDL-L were compared.There were statistical significant (P＜0.05).The ratio of hypertention,diabetes,high blood TC,high blood LDL-L, high CRP trend to increase with the development of carotid IMT.4.The correlation analysis of carotid intima-media thickness and cardiovascular risk factors:In double variable Spearsman correlation,the carotid IMT was associated with SBP,FBG,TC,TG and LDL-C significantly(P＜0.01).Sex and age were adjusted,we use partial correlation.Carotid IMT was not concerned with DBP and HDL-L(P＞0.05).Conclusion:There is a clear relativity between carotid IMT of EH patients and 'cardiovascular risk factor.The conglomeration of cardiovascular risk factor indicates that the greater serious symptom of carotid AS.