Interaction Of MTHFR Gene And Cardiovascular Risk Factors On Essential Hypertension

Objective:To investigate the interaction of methylenetetrahydrofolate reductase(MTHFR)SNP rs1801133 polymorphism with multiple cardiovascular risk factors and its relationship with the pathogenesis of essential hypertension(EH).Methods:A total of 741 patients with essential hypertension and 538 healthy controls were recruited as the research subjects.We used questionnaires to obtain the age,sex,smoking and drinking status,physical activity,and disease history of the respondents.And we measured the height,weight,heart rate,and blood pressure of the respondents at the same time.TaqMan method was used to detect the MTHFR rs1801133 genotype of all subjects.The generalized multifactor dimensionality reduction method(GMDR)and logistic linear regression model were used to analyze the interaction between rs1801133 and risk factors.Results:Hardy-Weinberg equilibrium test indicated that the study population was genetically balanced(P>0.05).The genotypes of CC,CT,and TT at rs1801133 locus were significantly different between patients and the control group(P<0.05,OR=1.387,95% CI: 1.038-1.830),while C,T allele frequencies were not significantly different between the two groups.GMDR results showed that rs1801133 interacted with age,BMI,heart rate,and lack of physical activity(P<0.05).Logistic linear regression model showed rs1801133 and age(RERI= 2.122,95% CI: 1.167-2.283),BMI(RERI=1.468,95% CI: 0.646-2.289),heart rate(RERI=2.539,95% CI: 0.678-4.400),Lack of physical activity(RERI=1.529,95% CI: 0.267-2.790)have synergistic interactions.Conclusion:SNP rs1801133 polymorphism is associated with the onset of EH,and TT genotype populations have a higher risk of EH.SNP rs1801133 have synergistic interactions with factors such as age,BMI,heart rate,and lack of physical activity.