The Study Of Serum Adiponectin, Resistin Level And Their Relationships With Arteriosclerosis In Obese Children

Objectives: To investigate the serum levels of adiponectin, High-sensitivity C-reactive protein, insulin, TG, HDL-C, LDL-C and 24hr ambulatory blood pressure, intima-media thickness of the common carotid artery, endothelium-dependent arterial dilation, the maximum fat thickness ahead of peritoneum, the minimum subcutaneous fat thickness in abdomen. We also analyze the relationships between adiponectin and the above-mentioned risk fators or markers of arteriosclerosis, study the effect of adiponectin in the arteriosclerosis process in obese children, obtain new ideas of preventing arteriosclerosis starting from childhood,and to determine whether high adiponectin level keep children from obesity and reduce the risk of developing arteriosclerosis and whether adiponectin level can be an early parameter of the metabolic syndrome of children.Methods: 32 non-obese children and 51 obese children were recruited for 24hr ambulatory blood pressure, including the mean systolic blood pressure and mean diastolic blood pressure. Endothelium-dependent arterial dilation, intima-media thickness of the common carotid artery(IMT), the maximum fat thickness ahead of peritoneum(Pmax), and the minimum subcutaneous fat thickness in abdomen(Smin) detected by B ultra sonograthy. The serum adiponectin, insulin were detected with ELISA and electrochemiluminescence assay respectively, the High-sensitivity C-reactive protein with scatter nephelomete method, TG and total cholesterol with enzymatic colorimetry, glutamic-pyruvic transaminase with continuous monitoring method, blood glucose with glucose oxidase method, and Serum free fatty acids with...