An Experimental Study Of Preventing After-Cataract With Rapamycin In Rabbit Eyes

ObjectiveAfter cataract is one of the most popular complications after ECCE or phacoemulsification. It mainly results from the proliferation , growth, migration and transdifferentiation of lens epithelial cells (LECs) left on the anterior capsule at the time of cataract surgery ,and some inflammatory cells may be participate. Rapamycin is a new macrolides immumosuppressive drug, which can inhibit the proliferation of T and B cell, smooth musule cells,endodermis cells and many other cells. In recent years, it has been widely used in organ transplantation and tumor trerapy. It also served as smear layer of blood vessel cage to prevent the restenosis of coronal artery. In ophthalmology, the cornea transplantation of annimals had been studied. It has been proved effectively in vitro to suppress the proliferation of the cultured LECs of rabbit. Therefore we apply Rapamycin into the anterior chamber irrigation solution of rabbits eyes during phacoemusification in order to assess whether RAPA has effect on preventing PCO. Methods...