A Study Of Hereditary, Metabolism Character And Psychology-related Factors In Type 2 Diabetic Pedigrees

Objective: To investigate the character of heredity and metabolism in first-degree relatives of type 2 diabetic pedigrees, and psychology-related factors which affected family members.Methods: From April, 2003 to June, 2005, outpatients or inpatients with type 2 diabetes mellitus (T2DM) who had family history, were chosen as probands from the first and second affiliated hospital of Dalian Medical University, Central Hospital, Friendship Hospital, 305 people were received from 91 type 2 diabetic family (probands 91 people, and first-degree relatives 214 people), and 76 spouses of probands were recruited at the same time, which totally was 381 people. Oral glucose tolerance test (OGTT) was conducted and diabetes diagnostic criteria established by WHO in 1999 was used, then first-degree relatives consisted of 119 non-diabetic subjects (NGT group) , 37 patients with impaired glucose regulation (IGR group), 58 type 2 diabetes (T2DM group), 44 non-diabetic spouses of probands without diabetic family history (control group). Fasting blood glucose, fasting insulin, fasting C peptide, 2 hour blood glucose, 2 hour insulin, 2 hour C peptide, triglyceride, total cholesterol et al were measured, and insulin resistance index (HOMA IR),β-cell function index (HOMAβ), insulin sensitivity index (ISI) , body mass index (BMI), waist hip ratio (WHR) were calculated. Symptoms checklist 90 (SCL₉0) being utilized, 137 subjects were selected for a mental questionnaire survey from 36 nuclear family.Results: (1) the prevalence of diabetes was 48.85% in 91 nuclear family, and it was 21.05% in spouses (control group), which were significantly different byχ² test (P=0.000); among the family members of...