Experimental Study Of Ji Chuan Jian In Treating Constipation And Relation Of Consenescence

OBJECT To investigate the effect of Ji Chuan Jian on gastrointestinal peristalsis of senile rats and study relevant mechanism. To investigate the effect of Ji Chuan Jian on senile index SOD ,MDA and MAO in mouse's liver and brain.METHODS The effect of Ji Chuan Jian on gastrointestinal peristalsis of senile rats was observed by small intestine charcoal powder propelling test. The levels of motilin, subtanee P and somatostain in small intestine of rats were determinated by radioimmunoassay. Using xantnin oxindase determin SOD;Using thiobarbituric acid determin MDA;Using cyclohexane extraction determin MAO.RESULTS Different dosage of Ji Chuan Jian can improve gastrointestinal peristalasis of senile rats and inerease the levels of motilin, subtance P, with reduce the content of somatostatin in small intestine of senile rats significantly. Ji Chuan Jian can significantly strengthen SOD activity and reduce content of MDA MAO in liver of senile mouse;Ji Chuan Jian can strengthen SOD activity and reduce content of MDA in brain of senile mouse.CONCLUSIONS Ji Chuan Jian can enhance the function of gastrointestinal peristalsis of senile rats by a mechanism of promoting excretion of motilin, subtanee P and lowering the level of somatostatin in intestine. Ji Chuan Jian seem had the effect of resisting decrepitude.