Association Of The TNF-α,Fas,MMP-7 Polymorphisms With Premature Rupture Of Membranes

Objective: Premature rupture of membranes (PROM) is one of the common obstetrical compilations that are threatening the health of mothers and infants, but the etiology and pathogenesis of it are still unclear now. More and more data suggest that PROM has endogenous base, and is associated with polymorphisms of some genes. So it can be considered as a genetic trait, in which multiple gene loci interact with each other and the environment to produce the disease phenotype. TNF-α, Fas and MMPs play important roles in initiation and development of PROM by enhancing inflammation,mediating apoptosis of membranes cells and degrading extracellular matrix (ECM). Some experiments have demonstrated that genetic variations in promoters of these genes may influence transcription and expression of proteins. The aim of this study is to assess the effects of the SNPs, the polymorphisms at the -308bp in the TNF-αpromoter, -670bp in the Fas promoter, and -181bp in the MMP-7 promoter, on the risk of premature rupture of membranes.Methods: 50 PROM neonates and 71 healthy term-delivered controls were included in our study, who were all...