| Objective: To investigate the effect on Quality-of-Life(QOL) of rate adaptive pacemaker in old patients with sick sinus symptom(SSS). Methods: 30 old patients had SSS accompanied with chronotropic incompetence in terms of clinical manifestation, h olter and tread mill were implanted the dual chamber pacing(DDDR). Pacemakers were respectively programmed without and with adaptive demand mode in the implantation instantly and 12months later. The SF-36 was used to measure quality of life without and with adaptive demand mode, the pacing rate, cardiac out-put and exercise capacity were measured by tread mill, echocardiography and holter during exercise test and daily activities in tow different mode. Results: The scores of SF-36 were significantly increased (118.6±7.12 VS 95.27±7.56, t=12.31, P<0.001) in DDDR mode and the scores about five aspects of SF-36, which included physical functioning, physical role, general health, vitality and social functional were better than in DDD mode.(except for body pain, emotional role and mental health).Compared with DDD mode, the exercise time and cardiac out-put of 30 patients were significantly increased(386.20±67.72s VS 274.10±56.88s, t=6.94, P<0.001; 9.97±1.03 1/ min VS 6.30±0.79 1/ min, t=15.41, P<0.001). However there were no significant difference between the tow mode in the stroke volume (71.57±5.35ml VS 70.67±5.42ml, t=0.65, P=0.52) Conclusions: The implantation of DDDR improves health-related quality of life, meet with requirement of...
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