Study Between Pathogenesis Of Pityriasis Rosea And Human Herpesvirus 7 And The Subsets Of T Lymphocyte Of Peripheral Blood

Objective To investigate the relationship between pathogenesis of pityriasis rosea(PR) and human herpes virus 7 and the change of the subsets of T lymphocyte of peripheral blood.Methods 36 PR patientsaged between 11-58 whose diagnoses were confirmed. And 36 healthy volunteers as control were included in the study. Nested polymerase chain (PCR) with specific primers for HHV -7 DNA sequences was performed on each blood sample and the results were analyzed by chi-square test. The subsets of T lymphocyte were measured by SAP and the results were analyzed by t-test.The correlations between HHV-7 and the subsets of T lymphocyte were measured by Wilcoxon Two-Sample Test.Results ①There was statistically significant difference for the presence of HHV-7 sequence between the PR patients (88.89%) and the control (52.78%,X~2 =9.68,P<0.01).② The proportions of CD3~+ T lymphocyte were significantly lower in the PR patients (65.27 ± 5.04) than those in the control (71.56 ± 4.45,t=5.09,P<0.01). The proportions of CD4~+T lymphocyte were lower in the PR patients (41.66± 4.75) than those in the control (44.53+6.71,t=2.07,P<0.05). The proportions of CD8~+ T lymphocyte were significantly higher in the PR patients (40.07 + 5.63) than those in the control (34.58 ±3.86,t=4.76,P<0.01). The ratio of CD4~* to CD8~+ was significantly lower in the PR patients than those in the control (1.12:1.30, t=4.31, P<0.01).③ The ratio of CD4~+ to CD8~+ was significantly lower in the HHV-7 positive people than those in the HHV-7 negative people.Conclusion ①The results indicated that the presence of HHV -7 DNA sequences was significantly higher in the PR patients than those in the control. We presumed that HHV-7 may be involved in the pathogenesis of PR. ② The ratio of CD4~+ to CD8~+ was significantly lower in the PR patients than those in the control. It indicated that cellular immunity may be involved in the pathogenesis of PR.