Effect On TNF-α And Ang-Ⅱ Of Serum Of Experiment Rat With Congestive Heart Failure Treated By Lixin Ⅰ

Objective: To study the effect of LiXin Ⅰ the a-Tumor Necrosis Factor and Angiotensin Ⅱ gravity of serum of the experimental rat with Congestive Heart Failure..METHODS: Eighty four Wistar rats were selected and divided randomly into six groups :one group of them in the normal control group ;others in the model groups established by intraperitoneal injection of Adriamycin. The later was classified as follow:the control model group admonished with physiological saline ;the XinBao treatment model group admonished with XinBao mixed liquid ;the medicine treatment model group admonished with Enalapril tablet mixed liquid ;the small dose LiXin Ⅰ treatment model group admonished with Li Xin Ⅰ mixed liquid(13.0g/kg) ;the large dose LiXin I treatment group admonished with LiXin I mixed liquid(26.0g/kg). All treatment groups had continually admonished by oral gavage one time a day.food and drink were given as usual.After four weeks,blood was obtained from rat carotid artery under the aneshthesia state and TNF-α and Ang Ⅱ were tested.RESULT:The experiment results show :firstly,TNF-α of serum of rat in the control model group is higher than in the normal control group (p<0.01) . TNF-α of serum of rat in the treatment groups is lower than in the control model group(p<0.01).TNF-α in the large dose LiXin Ⅰ treatment model group is lower than in the small dose LiXin Ⅰ and medicine treatment group respectively.Di-fference between them is obvious(p<0.05). secondly , Ang Ⅱ of serum in the control model group is higher than in the normal contrst group and treatment groups .Ang Ⅱ in the large dose LiXin I treatment group is lower than in the XinBao treatment group and in the small dose LiXin treatment group respectively (p<0.01). CONCLUSION: LiXin Ⅰ can...