| Objective: To explore curative effect of Lixin I on CHF through detecting the index of TNF-α AngⅡ and 6 minutes walk test in patients' blood.Methods: Forty cases were randomly devided into treatment group and control group. Patients in the control group we're treated by west medicine, while patients in the treatment group were treated by Lixin I 150ml every time twice every day on the basis of conventional treatment. Deploying RIA to detect the changing concentration of Angll and TNF-α in the two groups of patients'blood, At the same time, according to the method in the Vera Bittner's report, the change were observed by 6 minutes walk test before and after treatment. The curative effect on CHF in Lixin I were also observed.Results: The content of TNF— α, AngⅡof the treatment group had degraded more obviously than that of the control group, and the difference was significant (P<0.05) . The index of patients' heart function such as the distance of 6 minutes walk test , EF ,FSand E/A had improved greatly (P<0.05) .The treatment group outweighed the control group in the aspect of clinical evolution (P<0.05) .Conclusions:1.Every index of heart function in patients of CHF was ameliorated significantly by using Lixin I , which demonstrated the prescription possessed the better effect on improving the heart function.2. Lixin I could decrease the concentration of TNF-α, AngⅡ in the patients' blood of CHF obviously, which revealed the mechanism of action against cardiac failure could be the regulation of endocrine system in the patients with CHF by using Lixin I .3. Lixin I is an effective prescription, depending on the basic law which is tonifying pneuma, warming Yang, promoting blood flow and using diuretic of gydragogue to alleviate water retention. |
