| Objective To study the relationship of the plasma brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), tumor necrosis factor-a(TNF-a) and Interleukin-6(IL-6) concentration with the severity of heart failure, the undering heart disease and the left ventricular function in patients with congestive heart failure(CHF).Method 80 patients with CHF were recruited and divided into 3 subgroups of NYHA â…¡-â…£,and 30 healthy persons were enlisted as the control group. The blood samples were obtained from all the subjects in fasting condition in the morning. The levels of plasma BNP, ANP, TNF-otand IL-6 were determined by radioimmunoassay. Left ventricular ejec-tive fraction (LVEF) was measured by echocardiography.Results The plasma BNP, ANP, TNF-a and IL-6 concentrations were significantly higher in CHF groups than those in control group (P<0.01). They also increased according to the severity of heart failure classified by NYHA's classification (P<0. 01). The plasma BNP level was significantly higher in MI group than those in VHD,HHD and DCM group (P<0. 01). The levels of ANP, TNF-a and IL-6 were not related to the primary disease of CHF(P>0. 05). The plasma levels of BNP, ANP, TNF-aand IL-6 had significant negative correlation to LVEF (r=-0. 72,-0. 65,-0. 54 and -0. 58, P<0. 01, 0. 01, 0. 05, 0. 05). There were positive correlations among the level of TNF-a and those of BNP, ANP and IL-6 (r=0. 51, 0.45, 0.62, P<0. 01, 0.01 0.001).Conclusion (1) BNP, ANP, TNF-aand IL-6 serving as neurocrines and cytokines are involved in the pathophysiology of CHF. They also increased according to the severity of heart failure. (2) The plasma BNP concentration is elevated more markedly in CHF patients caused by myocardial infarction. (3) The plasma BNP concentration evaluates the left ventricular function better. (4) Neurocrines and cytokines relate each other and both play important roles in the diagnosis and the risks of patients with CHF.
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