The Change Of Secretory Type Ⅱ Phospholipase A2 In Acute Coronary Syndrome And The Relationship With CRP

Objective:Inflammatory reaction is an important feature in the process of atherosclerosis.In recent studies, the level of secretory type II phospholipase A2(sPLA2) were found to increase in some chronic inflammatory diseases such as rheumatic arthritis and inflammatory bowel disease. The results of research abroad show that the sPLA2 were highly expressed in atheromatous plaque, and that the lipid products generated through sPLA2 and their related products, including modified LDLs, play a significant role in the pathogenesis of coronary artery disease(C AD).While it can hardly been seen of such related reports in domestic field. So, the purpose of this article is to study the change of sPLA2 in acute coronary syndrome and the relationship with CRP.Methods:According to clinical syndrome and angiography, 43 patients were enrolled asacute coronary syndrome(ACS) group, 20 patients as stable coronary heart disease(SCHD) group and 23 non—CHD patients as control group. All the patients above were excluding infections and other inflammatory disease. Serum levels of sPLA2 was measured by ELISA in all subjects and that of CRP ware measured on AU2700 analyser. The analyses were performed by using SPSS Professional Statistics 10.0. Statistical significance was defined as P<0.05.Results:1. Sex, hypertension and diabetes have little influence on the level of sPLA2.2. Compared with control group, the level of serum sPLA2 was significantly higher in CHD group(115.55±20.61u/ml vs 162.13±41.10u/ml, P<0.01), which was also higher in ACS group than that in SCHD group(1171.31±41.68u/ml vs 142.37±32.73u/ml, P<0.01).The same changes occur in CRP, too.3. The level of serum sPLA2 was positively correlated with CRP(r=0.264, P=0.014) and WBC(r=0.255, P=0.018), but negatively correlated with HDL-C(r= -0.224, P=0.038). And it has no correlations with age, BMI and LDL-C.Conclusion:The increasing level of serum sPLA2 is correlated with CHD and it is muchhigher in ACS patients, which may reflect the unstability of coronary plaque. What's more, it is also positively correlated with CRP.