Correlation Analysis Of Lipoprotein-associated Phospholipase A2 And Premature Coronary Heart Disease

Objective To investigate the correlation between plasma lipoprotein associated phospholipase A2(LP-PLA2)level and the severity of premature coronary heart disease(PCHD).Methods 245 selected cases from January 2017 to January 2019 were divided into non-chd group(control group,100 cases)and PCHD group(observation group,145 cases)according to the results of coronary angiography.The PCHD group was divided into 34 cases of acute myocardial infarction(AMI)group,58 cases of unstable angina pectoris(UAP)group and 53 cases of stable angina pectoris(SAP)group according to the clinical characteristics.According to the results of coronary angiography,there were 69 cases in the single branch group,40 cases in the double branch group,and 36 cases in the three-branch group.The fasting serum LP-PLA2 level and other clinical data were tested.Results(1)the observation group LP-PLA2,TC,ldl-c were significantly higher than the control group,hdl-c was significantly lower than the control group,and Gensini score was significantly higher than the control group.(2)the LP-PLA2 and Gensini scores of the multi-branch disease subgroup were higher than those of the single-branch and double-branch disease groups,and the indexes of the double-branch disease group were higher than those of the single-branch disease group.(3)Pearon correlation analysis showed that serum LP-PLA2 was positively correlated with Gensini in patients with coronary heart disease,and the difference was statistically significant(r =0.681,P<0.001).Conclusion Serum LP-PLA2 is significantly higher in PCHD patients than in the control group,and is positively correlated with the severity of coronary heart disease.Serum LP-PLA2 levels can be used to assess the severity of disease in PCHD patients.