| 1 Association of cardiovascular risk factors and small arterial elasticityObjectives Based on case-control study, we explore what are major cardiovascular risk factors affecting small arterial elasticity and if small arterial elasticity decreases significantly in patients with multiple risk factors.Methods (1) 232 eligible subjects were recruited in this study. Arterial elastic indexes ( Cl-large artery and C2-small artery) were measured with CVProfilor DO-2020 artery pulse contour analysis instrument. Abnormal C2 group (n=119) and control group (n=11 13) were divided according to the levels of C2. (2) Meanwhile, the medical history, physical exam and biochemistry variables were collected. (3) According to the number of major cardiovascular risk factors, 232 subjects were categorized into four subgroups (0 to 3).Results (1) The levels of age, cholesterol (CHOL), low density lipoprotein- cholesterol (LDL-C), serum glucose, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in abnormal C2 group were significantly higher than that in control group, while the levels of C2 were lower than that in control group. (2) The levels of age, CHOL, LDL-C, serum glucose, SBP and DBP were negatively correlated with C2. (3) The levels of C2(ml/mmHg X 100) were 6.5+ 2.6(subgroup 0),5.4+2.3(subgroup 1),4.7 + 2.7(subgroup 2),3.1 + 1.6(subgroup 3) respectively. The levels of C2 were statistically different between any two subgroups (P<0.05) except between subgroup 1 and subgroup 2(P=0.073). (4) The levels of C2 were negatively correlated with the number of major cardiovascular risk factors (r=-0.409,P<0.001). Conclusions (1) Aging and abnormalities of CHOL, LDL-C, serum glucose, SBP and DBP were major cardiovascular risk factors of small arterial elasticity. Their effects on C2 were continuously linear. (2) Small arterial elasticity in patients with multiple risk factors decreases more significantly than that in patients without apparent risk factors. It is suggested they may have cooperative effects on small arterial elasticity.?2 Association of polymorphism of alpha-adducin gene and small artery elasticityObjectives To investigate the association of the polymorphism of alpha-adducin gene with small artery elasticity.Methods (1) Small artery elasticity index (C2) was measured with CVProfilor DO-2020. (2) Genotypes were determined by mutagenic separated PCR (MS-PCR)-agarose gel electrophoresis. Results (1) The frequencies of Trp/Trp genotype and Trp allele in abnormal C2 group were significantly higher than that in control group (33.6% vs 14.8%,P<0.01;56.0% vs 46.0%,P<0.05). (2) C2. SBP and DBP in Trp/Trp genotype were significantly different from that in Gly/Gly+Gly/Trp genotype (P<0.05). (3) After the influences of ten environmental factors were excluded through logistic regression analysis, Trp/Trp genotype was still the risk factor associated with abnormal C2 (P=0.032, OR=2.3, CI 1.1 -5.0).Conclusions The polymorphism of alpha-adducin gene is associated with small artery elasticity. Trp/Trp is a sensitive genotype reflecting the abnormality of small arterial compliance. 3 The effect of antihypertensive therapy on intima-media thickness of the common carotid artery and vascular complianceObjective To investigate the effect of antihypertensive therapy on intima-media thickness (IMT) of the common carotid artery(CCA) and vascular compliance.Methods 116 subjects were divided into three groups,45 normotensive individuals as the control group,35 subjects in controlled hypertension group, and 36 patients in uncontrolled hypertension group. Blood pressure and artery compliance (Cl-large artery,C2-small artery) were detected using HDI DO-2020. IMT of CCA was measured using HP5500 ultrasound with a high-resolution 7.5MHz scan head. Results IMT of the CCA of EH-uncontrolled group was markedly increased, compared with control group and EH-controlled group (P<0.01), but there was no statistical difference between control and EH-controlled groups(P>0.05).Lumen diameter(LD) of CCA between control and EH-uncon...
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