| The position which the neonates with lung disease should take is a question what neonatologists dispute about. There are many studies on effect of supine and prone position on oxyrenation and lung mechanics in heathy preterm infants and neonates with acute respiratory distress syndrome, but in neonates with pneumonia is unknown. It was the purpose of the study to evaluate the effect of supine and prone position on the ventilation and gas exchanging of preterm and term infants with pneumonia, the results would help to find an optimum nursing position.Material and Methods1. Subjects32 neonates with pneumonia were studied. When they were breathing air, their TcSO2 should be less than 90%. The infants were devided into preterm group and term group according to gestational age and birth weigh. Preterm group included 18 infants: male 10, female 6; mean gestational age 34.6 1.5w, postnatal age 2.5 1.4d, birth weight 2.2 0.4kg, study weight 2.0 0.4kg, Fraction of inspired oxygen 0.41 0.05. Term group included 14 infants: male 8, female 6; mean gestational age 38.9 l.lw, postnatal age 3.4 2.3d, birth weight 3.5 0.7kg, study weight 3.3 0.7kg, Fraction of inspired oxygen 0.4 0.06.2.Methed(1) ProcedureFiO2 shuld maintain the TcSO2 of the preterm be 89-92% and term infants be 89-95%. The infants were studied at least 30 minutes following completion of a feeding. Each infant was studied in both supine andprone, the order of which was chosen at random. The initial ten minutes following a change in position was not recorded. Inspired oxygen concentration and respiratory rate were determined three times in each position and the average values were recorded. Then the arterial blood gas sample was collected and was analyzed at once.(2) ApparatusOxygen analyzer, NPB-100 pulse oximeter and AVLCOMPACT2 blood gas analyzer.(3) Datealveolar-arterial oxygen tensiongradient (A-aDO2), arterial oxygen tention/inspired oxygen concentration (PaO2/FiO2), arterial oxygen tention/alveolar oxygen tention (PaO2/PAO2), arterial oxygen tention (PaO2), respiratory rate (RR), arterial carbon dioxide tention (PaCO2)(4)Statistical analysisAll data were presented as mean+SD. Statistical analysis of the results was carried out with pair t test.ResultIn the preterm group, PaO2 in the prone position was signicantly higher than in the supine position(68.4+11.8v60.7 9.8mmHg P<0.01); PaO2/FiO2 in the prone position was signicantly higher than in the supine position(l69.3 42.lv 149.3 35.5mmHg P<0.01); PaO2/PAO2 in the prone position was signicantly higher than in the supine position (0.3 0.09v0.28 0.069 P < 0.01 ) ;A-aDO2 in the prone position was signicantly lower than in the supine position (156 39.1vl64.8 35.7 mmHg P<0.01); PaCO2 in the prone position and in the supine has no statistical difference (55.8 9.7v 56.7 8.9 mmHg P>0.05) ; RR in the prone position and in the supine has no statistical difference (55.2 8.4v 56.4 8.6bpmP>0.05)In the term group, PaO2 in the prone position was signicantly higherthan in the supine position(70.1 13.5v63.8 13.9mmHg P<0.01); PaO2/FiO2 in the prone position was signicantly higher than in the supine position(180.4 33.4vl62.4 34.8mmHg P<0.01); PaO2/PAO2 in the prone position was signicantly higher than in the supine position (0.34 0.081v0.31 0.083 P<0.05); A-aDO2 in the prone position was signicantly lower than in the supine position (150.1 55.1 vl65.9 41.5 mmHg P<0.01); PaCO2 in the prone position and in the supine has no statistical difference(55.2 9.8v 55.9 12.5 mmHg P>0.05) ;RR in the prone position and in the supine has no statistical difference (52.8 8.0v 53.6 7.9bpmP>0.05) .Conclusion1. In the preterm and term infants with pneumonia who need inspiring oxygen, PaO2 PaO2/FiO2 and PaO2/PAO2 in the prone position were signicantly higher than in the supine position, A-aDO2 in the prone position were signicantly lower than in the supine position.2. In the two groups, the two position had no effect on ventilation.3. In both p...
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