Clinical Study Of Effect Of Shuguan Droplet Pills On Unstable Angina With The Weakness Of Yang With Stagnation Of The Blood And Retention Of Phlegm

Objective: TO observe the clinical effect of Shuguan Droplet pills(舒冠滴丸,SGDP)on the patients with the weakness of Yang with stagnation of the blood and retention of phlegm(阳虚痰瘀证,WYSR)in treating chronic unstable angina (UA)of Coronary heart disease(CHD)and to explore the clinical mechanism by the blood lipid, left ventricular systolic function and c-responsive protein (CRP).Methods: 60 cases with WYSR of UA were randomly, double-blindly divided into convention and treatment group. Each group had 30 cases. The treatment group was treated with oral SGDP(10pills,three times daily),while the convention group done with oral composite Dansen Droplet pills(CDDP,10pills,three times daily)during 4 weeks. The variation of angina pectoris symptoms, ECG, dosage of Nitroglycerin, blood lipid, left ventricular systolic function and CRP were observed before and after therapy.Results: The transient eradicate ache function, the change of　ECG of patients has been changed significantly in both group, but there was no difference each other (p>0.05).While 4 weeks later, SGDP not only appeared to be more effective than CDDP in improving symptoms(p<0.01),long-term eradicate ache function (p<0.01),but also seems to be superior to CDDP in decreasing the dosage of Nitroglycerin after 4 weeks (p<0.01),the blood level of TC and CRP (P<0.01).The level of SV,CO and EF of left ventricular had increased correspondingly (p<0.01).SGDP seems to be superior to CDDP in CO and EF (P<0.01) but inferior to CDDP in SV(P<0.05). Both group had no toxic and side function significantly.Conclusion: SGDP is a more effective drug in treating WYSR of chronic UA.