The Research Of Serum Paraoxonase Activity In Acute Cerebral Infarction

Background and Aim: Paraoxonase (PON) is a kind of glycoprotein synthesized by liver. PON has anti-atherosclerosis action. Recent research indicated that the activity of paraoxonase has a very marked decrease in some diseases, such as coronary artery disease, myocardial infarction and diabetes, then considered that decrease of its activity was a high-risk factor in these diseases. Our aim is to explore the relationship between serum paraoxonase activity and acute cerebral infarction.Subjects And Methods: In these two groups, each with 40 individuals, one is acute cerebral infarction group including 22 males and 18 females, the other is healthy control group including 24 males and 16 females. The patients of acute cerebral infarction group have an average age of 60.4± 8.6 years, the individuals of control group have an average age of 58.5 ± 9.2 years. 4 ml of blood from all individuals were taken from cubital vein on the condition of an empty stomach, then were centrifuged so as to separate serum which werepreserved at -20℃ without any added anticoagulant. Measurement of PON1 activity is by the approach of phenylacetate. The measured results were expressed as X ± S. Statistical significance of the data was assessed by analysis of t-test for quantitative data with two groups , analysis of variance for quantitative data with more than two groups and X2-test for categorical data.Results: Serum PON1 activity had a significant fall in the patients of acute cerebral infarction group compared with individuals of the healthy control group(P<0.05). HDL of both two experimental groups didn't appeared a significant difference(P>0.05). PON1 Activity/HDL in the acute cerebral infarction group compared to that in the control group had still a significant difference. There were no significant difference in each group with different sexes and ages. In the acute cerebral infarction group, PON1 activity of the patients with the diabetes complication had a significant difference compared to the patients with no complication (P<0.05).Conclusions: The decrease of PON1 activity is relative to the acute cerebral infarction, especially, to the patient with the diabetes complication. Decrease of PON1 activity can be a independent dangerous factor for the acute cerebral infarction. Our study established a theoretical foundation for the mechanics, diagnosis and treatment of the acute cerebral inarction.