| Abstract] Objective The aim of this study is to demonstrate the characteristics of dynamic changes of endothelm (ET) and nitric oxide (NO) in patients with intracerebral hemorrhage and investigate the clinical effects of magnesium sulfate in neural protection. Methods Fortyfive patients with intracerebral hemorrhage are devided into two groups. 1 twenty five patients in routine therapy 2.twenty patients using MgSO4 besides routine methods.Plasma level of ET and serum level of NO are measured in all patients with intracerebral hemorrhage serially on the 1st day... the 3rd day-s the 7th day and the 14th day. Twenty age-and-sex- matched healthy subjects are tested as control group. Results The level of ET significantly elevates on the 1st day~ the 3rd day and the 7th day, the level of ET is highst on the 3rd day,then decreases gradually ,on the 14th day it returns to the control concentrations ,furthermore, the elavation of ET is correlated positively with the amount of hemorrhage (pO.05). The level of NO and the level of ET have no relationship. Conclusion The alteration of ET and NO levels is remarkable in patients with acute intracerebral hemorrhage . It may reflect that ET and NO play an important role in the process of hemorrhage III El ~fl NO ~ pathophysiology.The plasma level of ET has a positive relationship with the amounts of hemorrhage,the level of ET significantly decreases in the group using MgSO4 than the group with routine methodes, it may reflect that magnesium sulfate has neural protection to some extent in acute intracerebral hemorrhage.
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