The Study Of Plasma ADH Levels In Primary Nocturnal Enuresis

Objective:To clarify the role of ADH in the pathogenesis of primary nocturnal enuresis(PNE).Patients and Methods: The study comprised 77 PNE patients (without organic abnormalities) aged 5-15 years and 38 normal children with age-matched. The plasma ADH levels were measured by RJA under the same water intakes at 1:00 am and 3:00 pm (ADHland A1-1D3 stand for them respectively) .The blood and urine osmolalities were determined at the same time.Results:The plasma ADH1 level of the controls was significantly higher (p < 0. 001) than ADH3 level (87.29?22. 45, 55.49?5.97 ng/L respectively). There was no significanty difference ( P >0.05) between ADH1 and ADH3 levels in the patients (59.11?5.45 and 66. 84?2.82 ng/L). Compared with the controls, there is significant difference (P < 0.001) in ADH1 levels and there is no in ADH3 levels (P >0.05 ) .We cannot find the significant differences of blood osmolalities between and within the two groups at 3pm and lam.The same results happened to the urine osmolatities.Conclusions:The ADH secretion peak at night (lam) does exist in nomal children but lack in the PNE patients. The results of the study suggest that decreased nocturnal ADH secretion is a cause of bedwetting.