Correlation Between The Syndrome Classified By Traditional Chinese Medicine And Reserved Function Of Liver In Patients With Primary Liver Cancer

Primary liver cancer (PLC) is a kind of malignant neoplasm, which occurs in the hepatocyte or in the epithelial cell of bile duct. In Traditional Chinese Medicine (TCM), it is described under such headings as istention of abdomen? accumulation of the liver? bdominal mass, ass in the abdomen? aundice? ypochondriac pain? and isease of sudden onset? There is a high incidence of PLC in our country, and the proportion of the disease is 43.7 percent on global scale .The clinical manifestations of PLC are progressive enlargement of the liver, pain, jaundice, fever, ascites, hemorrhage and AFP-positive. In our country, patients with PLC have two obvious pathological characteristics. One is that most of them have already reached a medium or advanced stage when they go to see their doctors, the other is that 84.6 percent of them have liver cirrhosis. Therefore, for them there is no best method to cure the disease according to modern medicine at present. Because of poor reserved function of liver, operation, chemotherapy, radiotherapy and TACE or TAE cannot be in common use. In China, many patients with PLC are accompanied by hepatitis and cirrhosis of liver and their economic conditions are very poor. For them, TCM has a unique advantage in the treatment of PLC over modern medicine. The research of treating PLC with TCM includes many fields. One of them is selection of treatment based on the differential diagnosis. And it is a kind of primary way to treat diseases in TCM. Because the selection of treatment based on the differential diagnosis in TCM has not yet been standardized at present, it is very difficult to evaluate the effectiveness of treatment and popularized it .So it is of great importance to make a united standard of differential diagnosis and do it objective, which will establish theoretical basis for the selection of treatment based on the differential diagnosis and improve the clinical effectiveness. Objective: perfecting the quantitative index relevant to specific syndrome of PLC, establishing assessing system of reserved function of liver, and systematically investigating the association between the two in order to provide objective basis for clinical treatment scheme of hepatic cancer and predicting prognosis. Methods: 28 eligible cases were collected and allocated three groups. They are respectively syndrome of liver heat and blood stasis, syndrome of liver hyperactivity and spleen deficiency and syndrome of deficiency of liver and kidney Yin. Then objective indexes were examined in all cases. 1. Comparison of three groups on all indexes including background of the disease (hepatitis and cirrhosis), stage, liver function grading, routine liver function (AST. ALT, ALB, GLO, A/G, TBiI, TBA, AKP. GGT, LDH and PT), AFP, ESR, cellular immunity function (NKC, LBT, CD4, CD8 and CD4/CDs), reserved function of liver (ICGRI5, OGTT curve, and OGTTR12O/60), Karnofsky and symptom by one-way analysis; 2. A multivariate analysis of significantly different indexes relevant to differential syndrome of TCM by multiple regressions. 3. A multivariate analysis between OGTTR12O/60 and routine liver function markers by stepwise regression. 4. The association between OGTTR12O/60 and ICGRI5 by simple regression. Results: 1. One-way analysis revealed that ALT, ALB, and A/G, TBII, PT, NKC, CD4 ICGRI5, OGTT curve, OOTTRI2O/60, Karnofsky -4-...