Study On Golgi Protein 73 And Related Indicators And TCM Syndromes Of Primary Liver Cancer

Objective: Starting from TCM syndrome differentiation,the differential expression of Golgi protein 73(GP73)and related indicators in different types of TCM syndromes of primary liver cancer(hereinafter referred to as "liver cancer")is analyzed to provide a certain objective for objective TCM syndrome differentiation The clinical basis provides more ideas for TCM to identify and treat liver cancer.Methods: From January 2019 to December 2019,156 patients with primary liver cancer who were newly diagnosed in Henan Provincial Hospital of Traditional Chinese Medicine and Henan Provincial Cancer Hospital were collected,120 were male and 36 were female,aged 18 to 80;healthy There were 52 cases,36 men and 16 women,aged 18 to 80 years.Organize the western medicine cases and the four diagnosis data of TCM of the subjects,and record the laboratory-related indexes GP73,alpha fetoprotein(AFP),alanine aminotransferase(ALT),and aspartate aminotransferase(AST),total bilirubin(TBil),albumin(ALB),globulin(GLO),red blood cells(RBC),hemoglobin(Hemoglobin,HGB)),Platelets(PLT).SPSS 21.0 statistical software was used to analyze the data,and the test level was α = 0.05.Result:1 The causes of liver cancer include hepatitis B virus hepatitis,hepatitis C virus hepatitis and other factors.Among them,hepatitis B virus hepatitis accounted for 78.8%,other causes accounted for 17.4%,and viral hepatitis C accounted for 3.8%.2 There was a significant difference between GP73 in liver cancer group and healthy group.The level of GP73 in liver cancer group was higher than that in healthy group(P<0.001).3 In the liver cancer group,58 cases(37.2%)of qi stagnation and blood stasis type,46 cases(29.5%)of liver and gallbladder fever type,and 52cases(33.3%)of yin deficiency type of liver and kidney.4 There was no significant difference in age and sex between the syndromes in the liver cancer group(P> 0.05).5The positive expression rate of GP73 in liver cancer group was 50%.The positive expression rates of the three syndrome types were qi stagnation and blood stasis type 37.9%,liver and gallbladder fever toxic type 54.3%,and liver and kidney yin deficiency type 59.6%.There was no significant difference between the groups(P> 0.05).6 The positive expression rate of AFP in the liver cancer group was41.7%.The positive expression rates among the three syndrome types were:Qi stagnation,blood stasis type,32.8%,liver,gallbladder and heat toxic type,41.3%,and liver and kidney yin deficiency type.No statistical significance(P> 0.05).7 The level of GP73 between syndrome types in liver cancer group was liver-kidney yin deficiency type> liver and gallbladder heat toxin type> qi stagnation blood stasis type,and the liver and kidney yin deficiency type and qi stagnation blood stasis type were statistically significant(P <0.05);The levels of AFP between the syndrome types were hepatobiliary heat-toxic type,liver-kidney yin deficiency type,qi stagnation blood stasis type,but the three syndrome types were not statistically significant(P>0.05).8The levels of ALT in the liver cancer group were in the order of liver and kidney yin deficiency type,liver and gallbladder heat toxin type,qi stagnation and blood stasis type.The three types of syndrome were statistically significant(P <0.05);Hepatobiliary fever type,Liver-kidney yin deficiency type,Qi stagnation and blood stasis type,the three syndrome types are statistically significant(P<0.05);ALB levels between the syndrome types are hepatobiliary heat toxic type,Qi stagnation blood stasis type,Liver-kidney yin deficiency type,the three syndrome types are statistically significant(P<0.05);TBil level is in order of liver-kidney yin deficiency type,liver-biliary heat-toxic type,qi stagnation blood stasis type,but the three syndrome types are compared There was no statistical significance(P> 0.05);the level of GLO was in the order of hepatobiliary heat toxicity type,Qi stagnation and blood stasis type,liver and kidney yin deficiency type,but the three syndrome types were not statistically significant(P> 0.05).9The levels of RBC in the liver cancer group were in the order of hepatobiliary heat toxicity type,Qi stagnation and blood stasis type,liver and kidney yin deficiency type,but the three types were not statistically significant(P> 0.05);HGB levels in the liver cancer group between types From high to low,the qi stagnation and blood stasis type,liver and gallbladder heat toxic type,liver and kidney yin deficiency type,the three types of syndromes are statistically significant(P<0.05);the level of PLT between the syndrome types of liver cancer group is stagnation Blood stasis type,Hepatobiliary heat toxicity type,Liver-yin deficiency type,the three syndrome types were statistically significant(P<0.05).Conclusion:1 GP73 has certain value in the diagnosis of Qi stagnation and blood stasis type and liver and kidney yin deficiency type in traditional Chinese medicine syndrome of liver cancer.ALT,AST,ALB,HGB,PLT have certain value in the diagnosis of liver cancer with qi stagnation and blood stasis type,liver and gallbladder heat toxicity type,liver and kidney yin deficiency type.2 The positive expression rates of GP73 and AFP,TBil,GLO,RBC failed to provide a reference value for the diagnosis of liver cancer syndrome of Qi stagnation and blood stasis type,liver and gallbladder heat toxicity type,liver and kidney yin deficiency type.3 ALT,AST,ALB,HGB,PLT have a certain reference value for the evaluation and prognosis of the disease.The liver function of liver and kidney yin deficiency type is seriously damaged,and the stagnation of qi stagnation and blood stasis type and the liver and gallbladder heat toxicity type are relatively light.Liver and kidney yin deficiency type bleeding is more risky and the prognosis is poor.