| The concept of "the unity of nature and human" in Traditional Chinese Medicine,which is particularly incarnated in the theory of five evolutive phases and six climatic factors,focuses on how the natural environment affect human life.It is a significant issue to explore how to interpret and adopt the concept of "the unity of nature and human" into scientific research methods.In recent years,the incidence of infectious diarrhea in China continues to be high,and more than half of the high prevalence groups are children under the age of 5.Since the infectious diarrhea seriously damages the health of residents,it is important research to apply the concept of "the unity of nature and human " into this new era.Based on infectious diarrhea data,meteorological data,social environment data and five circuits and six qi data in the mainland of China,this study focused on the risk factors affecting the incidence of infectious diarrhea in China.Meanwhile we discussed the influence of "the unity of nature and human" concept and the theory of five circuits and six qi under the context of modern science.1 Objective(1)To explore the etiology,pathogenesis,treatment and prognosis of infectious diarrhea in Huangdi Neijing,especially the influence of five evolutive phases and six climatic factors on the incidence of infectious diarrhea;(2)Based on the incidence of infectious diarrhea in the mainland of China,this paper studies the epidemiological,regional and age characteristics of infectious diarrhea in the mainland of China,and discusses the sensitivity of different age groups and regions to various risk factors;(3)After adding different five evolutive phases and six climatic factors characteristics,the accuracy of artificial intelligence algorithm in predicting the incidence of infectious diarrhea is studied to determine the best five evolutive phases and six climatic factors characteristics in predicting the incidence of infectious diarrhea.2 Data and methods(1)DataMonthly climate data were obtained from the National Meteorological Information Center of China(http://data.cma.cn/),including precipitation,wind speed,temperature,vapor pressure,and relative humidity.Monthly social factors data were obtained from the Chinese National Bureau of Statis-tics(http://www.stats.gov.cn),containing the quantity of centers for disease control and prevention,the quantity of health supervision institute,the quantity of health technicians,the amounts of wastewater discharge,chemical oxygen demand emissions,nitrogen output,the weight of Feces that are harmfully treated and the forest cover-age rate.The data are publicly available.(2)MethodsThe random forest algorithm is applied to simulate the historical data of infectious diarrhea incidence,which is based on meteorological factors and social factors.The sensitivity of people from different age groups and different regions to various risk factors are analyzed(the prediction result is hereinafter referred to as the "original prediction result").On this basis,different types of five evolutive phases and six climatic factors characteristics(suiyun characteristics,zhuqi characteristics,keqi characteristics and "sitian/zaiquan" combination characteristics)are added to the infectious diarrhea prediction simulation.The advantages and disadvantages of the prediction effect after adding five evolutive phases and six climatic factors characteristics are compared,and the sensitivity to various risk factors of different age groups and people in different regions are studied(the prediction result is hereinafter referred to as"new prediction result").At the same time,the influence of different types of five evolutive phases and six climatic factors characteristics on the incidence of infectious diarrhea in China was analyzed.3 Results(1)The infectious diarrhea recorded in the Huangdi Neijing is closely related to five circuits and six qi conditions.The change of five evolutive phases and six climatic factors will lead to people’s infection with dampness-heat pathogen,cold pathogen or wind pathogen,which will further lead to the infection of infectious diarrhea.Among these,dampness-heat pathogen leads to infectious diarrhea most significantly.Therefore,in clinical treatment of infectious diarrhea,it is mainly to clear away heat,detoxify and diuresis.At the same time,it will also be combined with the schemes of Warming Yang,dispersing cold and strengthening health and dispelling wind.(2)A total of 14,396,560 cases of infectious diarrhea were reported during 2005-2017 in mainland of China.Cases aged under 5 years accounted for 46.78%(6,733,533/14,396,560)of all cases.(3)The cases of infectious diarrhea indicated a long-term increasing trend a peak from May to August and a nadir from November to February are observed annually.(4)The incidence of infectious diarrhea in the group with age under 5 years old increased mainly in the early autumn and winter,while the incidence in the group with ages over 10 years old increased mainly in summer.In comparison,the incidence of infectious diarrhea in the 510 age group stayed quite stable and was less sensitive to season change.(5)The number of infectious diarrhea cases increased in most of the provinces during 2005-2017.The primary cases lied in southeast coastal provinces when considering the increase of all age groups.Only among the over-5 age group we observe the reduced number of infectious diarrhea cases,which happened in Beijing and Zhejiang province.(6)Our research chooses "meteorological factors+social environment factors" as the original prediction and "meteorological factors+five evolutive phases and six climatic factors"as the new prediction.After adding different five evolutive phases and six climatic factors,the prediction effect of infectious diarrhea has been improved to varying degrees.Specifically,compared with the original prediction results,the mean average error(accuracy)of the new prediction results has been improved by 7%and the variance(stability)has been improved by 13.9%after adding suiyun characteristics;After adding zhuqi characteristics,compared with the original prediction results,the mean average error(accuracy)of the new prediction results has been improved by 10.5%and the variance(stability)has been improved by 28.05%;Compared with the original prediction results,the average mean square absolute value(accuracy)error of the new prediction results has been improved by 9.49%and the variance(stability)has been improved by 27%after adding keqi characteristics;After adding the"sitian/zaiquan" combination characteristics,compared with the original prediction results,the mean average error(accuracy)of the new prediction results has been improved by 9.6%and the variance(stability)has been improved by 26.8%.(7)The order of influence degree of five evolutive phases and six climatic factors on infectious diarrhea is:suiyun>keqi>zhuqi>"sitian/zaiquan" combination characteristics.(8)Most provinces in China have the highest incidence of infectious diarrhea in the year of "Shuiyun Taiguo".(9)Most provinces in China have the highest incidence of infectious diarrhea when the zhuqi is "Taiying Shitu".(10)Most provinces in China have the highest incidence of infectious diarrhea when the keqi is "Shaoyin Junhuo" or "Jueyin Fengmu".(11)Most provinces in China have the highest incidence of infectious diarrhea when the combination of "sitian/zaiquan" is characterized by "Taiying Shitu/Taiyang Hanshui".4 Conclusions(1)In the period of Huangdi Neijing,it has been recognized that the incidence of infectious diarrhea caused by five evolutive phases and six climatic factors is obvious and common.It can be considered that the change of five evolutive phases and six climatic factors is the main factor leading to infectious diarrhea.The understanding and treatment of infectious diarrhea by later doctors are in the same line with that in Huangdi Neijing.(2)In the mainland of China,children under 5 years old are at high infection risk of infectious diarrhea.This group not only accounts for nearly half of infectious diarrhea cases,but also is more sensitive to various risk factors.At the same time,there are significant differences in the sensitivity of people in different regions and ages to various risk factors,which suggests that we can adopt personalized infectious diarrhea prevention scheme,which can not only save the prevention cost,but also improve the prevention accuracy.(3)To fully understand the impact of infectious diarrhea on human health,we need to not only study the impact of infectious diarrhea on population structure,but also pay attention to the impact of various meteorological factors,social factors and five evolutive phases and six climatic factors that induce the onset of infectious diarrhea.This is the enlightenment of the concept of "the unity of nature and human" in Traditional Chinese Medicine on the risk factors of infectious diarrhea.In is also the establishment of an effective early warning system of infectious diarrhea. |
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