| Objective:Under the background of the implementation of Healthy China 2030 Plan,the medical treatment concept of prevention first,early intervention and optimized of health management has raised more and more attention.To evaluate the effect of health preserving medicine of Traditional Chinese Medicine(TCM),we enrolled patients with mild-to-moderate depression and anxiety disorder patients who were diagnosed stagnated Qi transforming into fire followed by traditional Chinese medicine differentiation.All the patients received the stand traditional Chinese medicine and western medicine treatment,meanwhile,Five Elements Music Therapy and Exercise therapy were also added to the therapeutic regimen.In this study,we explore the therapeutic effect of health preserving medicine of integration of motion and quietness and regulate mind under different syndrome,age and education background.By deep analysis the association of gender,age,education background and marital status with the disease,we hoping to optimize different five-element music schemes and exercise pattern and supply a research strategy and a treatment method for such kind diseases.Methods:This is a prospective,multicenter and cohort study.From August 2018 to November 2019,we enrolled patients with both depression and anxiety disorders from Dongfang Hospital of Beijing University of Chinese Medicine,Dongzhimen Hospital of Beijing University of Chinese Medicine and Beijing Anding hospital.All the patients’ recessive a TCM evaluation and diagnosed stagnated Qi transforming into fire.Finally,a total of 150 patients were diagnosed stagnated Qi transforming into fire.Of them,75 patients were divided into regular Chinese medicine and western medicine treatment group(control group)and the other 75 were in health preserving medicine treatment group(treatment group).The therapeutic regimen were as follows:the control group were given Sertraline 50mg Qd with Dan Zhi Xiao Yao San for 8 weeks;the treatment group were given Sertraline 50mg Qd,Dan Zhi Xiao Yao San,music based on five elements and Ba Duan Jin for 8 weeks.The curative effect was evaluated based on Hamilton depression rating scale and Hamilton anxiety scale.The curative effect was evaluated by of nimodipine reduction rate.All the raw data were typed in by using EPIdata 3.1 and analysis with R software(Version:3.6.2)and using Nimodipine method for scale control.Results:(1)There were 55 male patients which accounting for 36.70%of the total participants;95 patients were female which accounting for 63.30%of the total participants.Of the total patients,most of them were between 18 to 30 years old which accounting for 36%of the total population.Of all the participants,most of them were undergraduate and junior college.After an 8 weeks treatment,there were significant difference in HAMD and HAMA between the two groups(P<0.05).Nevertheless,there were no significant association between two groups under gender,education background and marital status(P>0.05).In addition,there was no statistical difference between the treatment group and the control group(P>0.05)by measuring the score reduction rate,however,after 8 weeks treatment,the total effective rate in the treatment group were higher than the control group.(2)We made a subgroup analysis based on HAMD<7 and finally 91 patients were enrolled in analysis.Our results show that most of them were female(71.43%)and only 28.57%were male.Most of the patients were between 18 to 30-year-old which accounting for 39.56%.most of them were undergraduate and junior college(55.17%).There were no significant statistically differences between the treatment group and the control group in gender,marital status,educational background,and age(P>0.05).After 4 weeks treatment,the HAMD and therapeutic effects in two groups were all decreased(P<0.05).After 8 weeks treatment,compared with the control group,the HAMD score in treatment group was decreased,nevertheless,the significance was at the critical 95%confidence interval boundary(P>0.05).In addition,no statistical difference was observed between junior and senior high school education(P>0.05).There was a significant decrease of HAMA scale score in patients with master’s degree but no statistical difference was observed(P>0.05).In addition,the multiple regression analysis showed that there were no association between HAMD/HAMA reductive ratio and age,gender,education,marriage,and therapeutic regimen.Conclusion:(1)There was a higher incidence rate in female to develop a mild-to-moderate depression and anxiety disorder.The age of the disease onset is mainly between 18-30 years old people which was different with the exist study.(2)Health preserving therapy of traditional Chinese medicine added into routine drug treatment can alleviate dizziness,flustered insomnia,and psychological symptoms such as depression,depressed,anxious,irritable.Although compared with the conventional treatment group,the health preserving medicine treatment group does not showed the therapeutic advantage,the therapeutic effect of health preserving medicine treatment elevated with long intervention and observation.This had reminded us that added of health preserving therapy was with good stability and durability(3)After further analysis,we’d found that health preserving therapy of traditional Chinese medicine has a relatively prominent effect on the population with depression disorder.There is a possible correlation between educational background and therapeutic effect.The higher the educational background,the more obvious the effect.(4)Health preserving therapy which use music and exercise is a method that based on the regular treatment of traditional Chinese medicine and western medicine.It is the clinical practice of“Xin Shen Bing Tiao”and the extension of Healthy China Concept.Although the enrolled patients are limited,our study still has certain clinical significance and is worth of further study. |
PDF Full Text Request